BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci.

ME Haywood, L Gabriel, SJ Rose, NJ Rogers, S Izui, Bernard J Morley

Research output: Contribution to journalArticle

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Abstract

The BXSB strain of recombinant inbred mice develops a spontaneous pathology that closely resembles the human disease systemic lupus erythematosus. Six non-MHC loci, Yaa, Bxs1-4, and Bxs6, have been linked to the development of aspects of the disease while a further locus, Bxs5, may be a BXSB-derived disease suppressor. Disease development is delayed in a substrain of BXSB, BXSB/MpJScr-long-lived (BXSB/ll). We compared the genetic derivation of BXSB/ll mice to the original strain, BXSB/MpJ, using microsatellite markers and single nucleotide polymorphisms across the genome. These differences were clustered and included two regions known to be important in the disease-susceptibility of these mice, Bxs5 and 6, as well as regions on chromosomes 5, 6, 9, 11, 12, and 13. We compared BXSB/ll to >20 strains including the BXSB parental SB/Le and C57BL/6 strains. This revealed that BXSB/ll is a separate recombinant inbred line derived from SB/Le and C57BL/6, but distinctly different from BXSB, that most likely arose due to residual heterozygosity in the BXSB stock. Despite the continued presence of the powerful disease-susceptibility locus Bxs3, BXSB/ll mice do not develop disease. We propose that the disappearance of the disease phenotype in the BXSB/ll mice is due to the inheritance of one or more suppressor loci in the differentially inherited intervals between the BXSB/ll and BXSB strains.
Original languageEnglish
Pages (from-to)2428-2434
Number of pages7
JournalThe Journal of Immunology
Volume179
Publication statusPublished - Aug 2007

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Disease Susceptibility
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 6
Inbred Strains Mice
Systemic Lupus Erythematosus
Microsatellite Repeats
Single Nucleotide Polymorphism
Genome
Pathology
Phenotype

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BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci. / Haywood, ME; Gabriel, L; Rose, SJ; Rogers, NJ; Izui, S; Morley, Bernard J.

In: The Journal of Immunology, Vol. 179, 08.2007, p. 2428-2434.

Research output: Contribution to journalArticle

Haywood, ME, Gabriel, L, Rose, SJ, Rogers, NJ, Izui, S & Morley, BJ 2007, 'BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci.', The Journal of Immunology, vol. 179, pp. 2428-2434.
Haywood, ME ; Gabriel, L ; Rose, SJ ; Rogers, NJ ; Izui, S ; Morley, Bernard J. / BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci. In: The Journal of Immunology. 2007 ; Vol. 179. pp. 2428-2434.
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