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Heterocyclisation of tert-butyldimethylsilyl (TBS) protected γ-hydroxy-α,β-unsaturated ketones catalysed by para-toluenesulfonic acid (p-TSA) to form substituted furans is reported. The reaction proceeds under mild conditions at room temperature in methanol to give a range of furan products (21 examples, up to 98% yield). Mechanistic experiments suggest the reaction proceeds via in situ deprotection followed by catalytic dehydrative heterocyclisation.
FingerprintDive into the research topics of 'Brønsted acid-catalysed desilylative heterocyclisation to form substituted furans'. Together they form a unique fingerprint.
- 1 Active
19/11/21 → 18/11/23
Project: Research council