Abstract
The direct, catalytic dehydrative substitution of alcohols is a challenging, yet highly desirable process in the development of more sustainable approaches to organic chemistry. This review outlines recent advances in Brønsted acid-catalysed dehydrative substitution reactions for C-C, C-O, C-N and C-S bond formation. The wide range of processes that are now accessible using simple alcohols as the formal electrophile are highlighted, while current limitations and therefore possible future directions for research are also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 106-120 |
| Number of pages | 15 |
| Journal | Chemistry - A European Journal |
| Volume | 27 |
| Issue number | 1 |
| Early online date | 3 Jun 2020 |
| DOIs | |
| Publication status | Published - 4 Jan 2021 |
Bibliographical note
Funding Information:We thank the University of St Andrews and the EPSRC for the award of a DTA studentship (S.E.‐D.).
Publisher Copyright:
© 2020 The Authors. Published by Wiley-VCH GmbH
Keywords
- Brønsted acid
- alcohols
- dehydrative substitution
- homogeneous catalysis
- sustainable synthesis
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry