Boronic acids for fluorescence imaging of carbohydrates

Xiaolong Sun, Wenlei Zhai, John S. Fossey, Tony D. James

Research output: Contribution to journalArticle

41 Citations (Scopus)
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Abstract

"Fluorescence imaging" is a particularly exciting and rapidly developing area of research; the annual number of publications in the area has increased ten-fold over the last decade. The rapid increase of interest in fluorescence imaging will necessitate the development of an increasing number of molecular receptors and binding agents in order to meet the demand in this rapidly expanding area. Carbohydrate biomarkers are particularly important targets for fluorescence imaging given their pivotal role in numerous important biological events, including the development and progression of many diseases. Therefore, the development of new fluorescent receptors and binding agents for carbohydrates is and will be increasing in demand. This review highlights the development of fluorescence imaging agents based on boronic acids a particularly promising class of receptors given their strong and selective binding with carbohydrates in aqueous media.

Original languageEnglish
Pages (from-to)3456-3469
Number of pages14
JournalChemical Communications
Volume52
Issue number17
Early online date23 Nov 2015
DOIs
Publication statusPublished - 28 Feb 2016

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Boronic Acids
Carbohydrates
Fluorescence
Imaging techniques
Acids
Biomarkers

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Boronic acids for fluorescence imaging of carbohydrates. / Sun, Xiaolong; Zhai, Wenlei; Fossey, John S.; James, Tony D.

In: Chemical Communications, Vol. 52, No. 17, 28.02.2016, p. 3456-3469.

Research output: Contribution to journalArticle

Sun, Xiaolong ; Zhai, Wenlei ; Fossey, John S. ; James, Tony D. / Boronic acids for fluorescence imaging of carbohydrates. In: Chemical Communications. 2016 ; Vol. 52, No. 17. pp. 3456-3469.
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