Boronate based fluorescence (ESIPT) probe for peroxynitrite

Adam Sedgwick; Xiaolong Sun; Gyoungmi  Kim; Juyoung Yoon; Steven D. Bull; Tony D. James

doi:10.1039/C6CC06829D

Boronate based fluorescence (ESIPT) probe for peroxynitrite

Adam Sedgwick, Xiaolong Sun, Gyoungmi Kim, Juyoung Yoon, Steven D. Bull, Tony D. James

Ewha Womans University

Research output: Contribution to journal › Article › peer-review

114 Citations (SciVal)

Abstract

A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester “protecting” unit. The “protecting” unit of the probe is removed by peroxynitrite to “turn-on” ESIPT fluorescence (4.5 fold enhancement). Furthermore, the probe was cell permeable and was used in cell imaging experiments showing an off–on response towards peroxynitrite, in HeLa and RAW 264.7 cells.

Original language	English
Pages (from-to)	12350-12352
Number of pages	3
Journal	Chemical Communications
Volume	52
Issue number	83
Early online date	19 Sept 2016
DOIs	https://doi.org/10.1039/C6CC06829D
Publication status	Published - 25 Oct 2016

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10.1039/C6CC06829DLicence: CC BY

Boronate based fluorescence (ESIPT) probe for peroxynitrite
Sedgwick, A. (Creator), Sun, X. (Creator), Kim, G. (Creator), Yoon, J. (Creator), Bull, S. (Creator) & James, T. (Creator), University of Bath, 2016
DOI: 10.15125/BATH-00252
Dataset

Cite this

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title = "Boronate based fluorescence (ESIPT) probe for peroxynitrite",

abstract = "A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester “protecting” unit. The “protecting” unit of the probe is removed by peroxynitrite to “turn-on” ESIPT fluorescence (4.5 fold enhancement). Furthermore, the probe was cell permeable and was used in cell imaging experiments showing an off–on response towards peroxynitrite, in HeLa and RAW 264.7 cells.",

author = "Adam Sedgwick and Xiaolong Sun and Gyoungmi Kim and Juyoung Yoon and Bull, {Steven D.} and James, {Tony D.}",

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AU - Sedgwick, Adam

AU - Sun, Xiaolong

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AU - Yoon, Juyoung

AU - Bull, Steven D.

AU - James, Tony D.

PY - 2016/10/25

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AB - A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester “protecting” unit. The “protecting” unit of the probe is removed by peroxynitrite to “turn-on” ESIPT fluorescence (4.5 fold enhancement). Furthermore, the probe was cell permeable and was used in cell imaging experiments showing an off–on response towards peroxynitrite, in HeLa and RAW 264.7 cells.

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DO - 10.1039/C6CC06829D

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VL - 52

SP - 12350

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JO - Chemical Communications

JF - Chemical Communications

IS - 83

ER -

Boronate based fluorescence (ESIPT) probe for peroxynitrite

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Boronate based fluorescence (ESIPT) probe for peroxynitrite

Cite this