Boronate based fluorescence (ESIPT) probe for peroxynitrite

Adam Sedgwick, Xiaolong Sun, Gyoungmi Kim, Juyoung Yoon, Steven D. Bull, Tony D. James

Research output: Contribution to journalArticlepeer-review

109 Citations (SciVal)


A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester “protecting” unit. The “protecting” unit of the probe is removed by peroxynitrite to “turn-on” ESIPT fluorescence (4.5 fold enhancement). Furthermore, the probe was cell permeable and was used in cell imaging experiments showing an off–on response towards peroxynitrite, in HeLa and RAW 264.7 cells.
Original languageEnglish
Pages (from-to)12350-12352
Number of pages3
JournalChemical Communications
Issue number83
Early online date19 Sept 2016
Publication statusPublished - 25 Oct 2016


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