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The incidence of whooping cough caused by Bordetella pertussis in many developed countries has risen dramatically in recent years. This has been linked to the use of an acellular pertussis vaccine. In addition, it is thought that B. pertussis is adapting under acellular vaccine mediated immune selection pressure, towards vaccine escape. Genomics-based approaches have revolutionised the ability to resolve the fine structure of the global B. pertussis population and its evolution during the era of vaccination. Here, we discuss the current picture of B. pertussis evolution and diversity in the light of the current resurgence, highlight import questions raised by recent studies in this area and discuss the role that functional genomics can play in addressing current knowledge gaps.
|Journal||Foodborne Pathogens and Disease|
|Early online date||22 Aug 2015|
|Publication status||Published - 22 Aug 2015|
- Bordetella pertussis
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- 1 Finished
Transfer of Grant for Andy Preston - Development of a Systems Biology for Bordetella Pertussis Metabolism
Biotechnology and Biological Sciences Research Council
10/04/12 → 4/01/15
Project: Research council