Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series

Peter E.H. Schwarz, Patrick Timpel, Lorenz Harst, Colin J. Greaves, Mohammed K. Ali, Jeffrey Lambert, Mary Beth Weber, Mohamad M. Almedawar, Henning Morawietz

Research output: Contribution to journalReview articlepeer-review

33 Citations (SciVal)


The primary objective of this study was to analyze the most up-to-date evidence regarding whether and how blood sugar regulation influences cardiovascular health promotion and disease prevention by carrying out an umbrella review. Three separate, systematic literature searches identified 2,343 papers in total. Overall, 44 studies were included for data extraction and analysis. The included systematic reviews and meta-analyses published between January 1, 2016, and December 31, 2017, were of good to very good quality (median Overview Quality Assessment Questionnaire score = 17). Identified evidence suggests that cardiovascular disease (CVD) prevention services should consider regulation of blood glucose as a key target for intervention. Furthermore, the recommendations for effective intervention and service development/training described here for prevention of CVD should be adopted into evidence-based practice guidelines. Multidisciplinary teams should be formed to deliver multicomponent interventions in community-based settings. There may be substantial opportunities for integrating CVD and diabetes prevention services.

Original languageEnglish
Pages (from-to)1829-1844
Number of pages16
JournalJournal of the American College of Cardiology
Issue number15
Early online date1 Oct 2018
Publication statusPublished - 9 Oct 2018


  • blood glucose
  • diabetes mellitus
  • diet
  • exercise
  • health behavior
  • umbrella review
  • weight loss

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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