Bivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle

Carlos Eduardo Buss; Juliana Afonso; Priscila S.N. de Oliveira; Juliana Petrini; Polyana Cristine Tizioto; Aline S.M. Cesar; Emanuele Cristina Gustani-Buss; Tainã Figueiredo Cardoso; Gregori A. Rovadoski; Wellison Jarles da Silva Diniz; Andressa Oliveira de Lima; Marina Ibelli Pereira Rocha; Bruno Gabriel Nascimento Andrade; Jason B. Wolf; Luiz Lehmann Coutinho; Gerson Barreto Mourão; Luciana Correia de Almeida Regitano

doi:10.1007/s00335-022-09969-6

Bivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle

Carlos Eduardo Buss, Juliana Afonso, Priscila S.N. de Oliveira, Juliana Petrini, Polyana Cristine Tizioto, Aline S.M. Cesar, Emanuele Cristina Gustani-Buss, Tainã Figueiredo Cardoso, Gregori A. Rovadoski, Wellison Jarles da Silva Diniz, Andressa Oliveira de Lima, Marina Ibelli Pereira Rocha, Bruno Gabriel Nascimento Andrade, Jason B. Wolf, Luiz Lehmann Coutinho, Gerson Barreto Mourão, Luciana Correia de Almeida Regitano

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9 Citations (SciVal)

Abstract

Feed-efficient cattle selection is among the most leading solutions to reduce cost for beef cattle production. However, technical difficulties in measuring feed efficiency traits had limited the application in livestock. Here, we performed a Bivariate Genome-Wide Association Study (Bi-GWAS) and presented candidate biological mechanisms underlying the association between feed efficiency and meat quality traits in a half-sibling design with 353 Nelore steers derived from 34 unrelated sires. A total of 13 Quantitative Trait Loci (QTL) were found explaining part of the phenotypic variations. An important transcription factor of adipogenesis in cattle, the TAL1 (rs133408775) gene located on BTA3 was associated with intramuscular fat and average daily gain (IMF-ADG), and a region located on BTA20, close to CD180 and MAST4 genes, both related to fat accumulation. We observed a low positive genetic correlation between IMF-ADG (r = 0.30 ± 0.0686), indicating that it may respond to selection in the same direction. Our findings contributed to clarifying the pleiotropic modulation of the complex traits, indicating new QTLs for bovine genetic improvement.

Original language	English
Pages (from-to)	90-103
Number of pages	14
Journal	Mammalian Genome
Volume	34
Issue number	1
Early online date	4 Dec 2022
DOIs	https://doi.org/10.1007/s00335-022-09969-6
Publication status	Published - 31 Mar 2023

Bibliographical note

Funding Information:
We thank FAPESP (2012/23638-8) for financial support, and Brazilian Federal Agency for Support and Evaluation of Graduate Education – CAPES (Financing support code 001). We thank all the Staff of Embrapa Pecuária Sudeste responsible for monitoring and taking care of animals.

Funding

We thank FAPESP (2012/23638-8) for financial support, and Brazilian Federal Agency for Support and Evaluation of Graduate Education – CAPES (Financing support code 001). We thank all the Staff of Embrapa Pecuária Sudeste responsible for monitoring and taking care of animals.

ASJC Scopus subject areas

Genetics

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10.1007/s00335-022-09969-6

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Buss, C. E., Afonso, J., de Oliveira, P. S. N., Petrini, J., Tizioto, P. C., Cesar, A. S. M., Gustani-Buss, E. C., Cardoso, T. F., Rovadoski, G. A., da Silva Diniz, W. J., de Lima, A. O., Rocha, M. I. P., Andrade, B. G. N., Wolf, J. B., Coutinho, L. L., Mourão, G. B., & de Almeida Regitano, L. C. (2023). Bivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle. Mammalian Genome, 34(1), 90-103. https://doi.org/10.1007/s00335-022-09969-6

Buss, CE, Afonso, J, de Oliveira, PSN, Petrini, J, Tizioto, PC, Cesar, ASM, Gustani-Buss, EC, Cardoso, TF, Rovadoski, GA, da Silva Diniz, WJ, de Lima, AO, Rocha, MIP, Andrade, BGN, Wolf, JB, Coutinho, LL, Mourão, GB & de Almeida Regitano, LC 2023, 'Bivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle', Mammalian Genome, vol. 34, no. 1, pp. 90-103. https://doi.org/10.1007/s00335-022-09969-6

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title = "Bivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle",

abstract = "Feed-efficient cattle selection is among the most leading solutions to reduce cost for beef cattle production. However, technical difficulties in measuring feed efficiency traits had limited the application in livestock. Here, we performed a Bivariate Genome-Wide Association Study (Bi-GWAS) and presented candidate biological mechanisms underlying the association between feed efficiency and meat quality traits in a half-sibling design with 353 Nelore steers derived from 34 unrelated sires. A total of 13 Quantitative Trait Loci (QTL) were found explaining part of the phenotypic variations. An important transcription factor of adipogenesis in cattle, the TAL1 (rs133408775) gene located on BTA3 was associated with intramuscular fat and average daily gain (IMF-ADG), and a region located on BTA20, close to CD180 and MAST4 genes, both related to fat accumulation. We observed a low positive genetic correlation between IMF-ADG (r = 0.30 ± 0.0686), indicating that it may respond to selection in the same direction. Our findings contributed to clarifying the pleiotropic modulation of the complex traits, indicating new QTLs for bovine genetic improvement.",

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note = "Funding Information: We thank FAPESP (2012/23638-8) for financial support, and Brazilian Federal Agency for Support and Evaluation of Graduate Education – CAPES (Financing support code 001). We thank all the Staff of Embrapa Pecu{\'a}ria Sudeste responsible for monitoring and taking care of animals. ",

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AU - Petrini, Juliana

AU - Tizioto, Polyana Cristine

AU - Cesar, Aline S.M.

AU - Gustani-Buss, Emanuele Cristina

AU - Cardoso, Tainã Figueiredo

AU - Rovadoski, Gregori A.

AU - da Silva Diniz, Wellison Jarles

AU - de Lima, Andressa Oliveira

AU - Rocha, Marina Ibelli Pereira

AU - Andrade, Bruno Gabriel Nascimento

AU - Wolf, Jason B.

AU - Coutinho, Luiz Lehmann

AU - Mourão, Gerson Barreto

AU - de Almeida Regitano, Luciana Correia

N1 - Funding Information: We thank FAPESP (2012/23638-8) for financial support, and Brazilian Federal Agency for Support and Evaluation of Graduate Education – CAPES (Financing support code 001). We thank all the Staff of Embrapa Pecuária Sudeste responsible for monitoring and taking care of animals.

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N2 - Feed-efficient cattle selection is among the most leading solutions to reduce cost for beef cattle production. However, technical difficulties in measuring feed efficiency traits had limited the application in livestock. Here, we performed a Bivariate Genome-Wide Association Study (Bi-GWAS) and presented candidate biological mechanisms underlying the association between feed efficiency and meat quality traits in a half-sibling design with 353 Nelore steers derived from 34 unrelated sires. A total of 13 Quantitative Trait Loci (QTL) were found explaining part of the phenotypic variations. An important transcription factor of adipogenesis in cattle, the TAL1 (rs133408775) gene located on BTA3 was associated with intramuscular fat and average daily gain (IMF-ADG), and a region located on BTA20, close to CD180 and MAST4 genes, both related to fat accumulation. We observed a low positive genetic correlation between IMF-ADG (r = 0.30 ± 0.0686), indicating that it may respond to selection in the same direction. Our findings contributed to clarifying the pleiotropic modulation of the complex traits, indicating new QTLs for bovine genetic improvement.

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Bivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle

Abstract

Bibliographical note

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