Bivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle

Carlos Eduardo Buss, Juliana Afonso, Priscila S.N. de Oliveira, Juliana Petrini, Polyana Cristine Tizioto, Aline S.M. Cesar, Emanuele Cristina Gustani-Buss, Tainã Figueiredo Cardoso, Gregori A. Rovadoski, Wellison Jarles da Silva Diniz, Andressa Oliveira de Lima, Marina Ibelli Pereira Rocha, Bruno Gabriel Nascimento Andrade, Jason B. Wolf, Luiz Lehmann Coutinho, Gerson Barreto Mourão, Luciana Correia de Almeida Regitano

Research output: Contribution to journalArticlepeer-review

Abstract

Feed-efficient cattle selection is among the most leading solutions to reduce cost for beef cattle production. However, technical difficulties in measuring feed efficiency traits had limited the application in livestock. Here, we performed a Bivariate Genome-Wide Association Study (Bi-GWAS) and presented candidate biological mechanisms underlying the association between feed efficiency and meat quality traits in a half-sibling design with 353 Nelore steers derived from 34 unrelated sires. A total of 13 Quantitative Trait Loci (QTL) were found explaining part of the phenotypic variations. An important transcription factor of adipogenesis in cattle, the TAL1 (rs133408775) gene located on BTA3 was associated with intramuscular fat and average daily gain (IMF-ADG), and a region located on BTA20, close to CD180 and MAST4 genes, both related to fat accumulation. We observed a low positive genetic correlation between IMF-ADG (r = 0.30 ± 0.0686), indicating that it may respond to selection in the same direction. Our findings contributed to clarifying the pleiotropic modulation of the complex traits, indicating new QTLs for bovine genetic improvement.

Original languageEnglish
JournalMammalian Genome
Early online date4 Dec 2022
DOIs
Publication statusE-pub ahead of print - 4 Dec 2022

ASJC Scopus subject areas

  • Genetics

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