Biosensors for screening kinase inhibitors

Nikhil Bhalla, Pedro Estrela

Research output: Contribution to journalReview article

92 Downloads (Pure)

Abstract

For successful drug discovery it is important to understand the fundamentals of the underlying causes and consequences of the diseases for which the drug is being developed. One such physiological process in eukaryotic cells is protein phosphorylation, which is the main post-translational modification of proteins responsible for the onset or progression of Alzheimer's disease, diabetes and various cancers. Protein phosphorylation is facilitated by kinases and inhibitors of kinases act as drugs in controlling or curing these diseases by reducing protein phosphorylation. This review discusses the technologies capable of detecting kinase activity and screening candidate compounds to identify novel inhibitors of protein kinases.
Original languageEnglish
Pages (from-to)2470-2481
Number of pages12
JournalCurrent Topics in Medicinal Chemistry
Volume17
Issue number22
DOIs
Publication statusPublished - 30 May 2017

Fingerprint

Biosensing Techniques
Phosphotransferases
Phosphorylation
Physiological Phenomena
Proteins
Eukaryotic Cells
Drug Discovery
Post Translational Protein Processing
Protein Kinase Inhibitors
Pharmaceutical Preparations
Alzheimer Disease
Technology
Neoplasms

Keywords

  • Biosensors

Cite this

Biosensors for screening kinase inhibitors. / Bhalla, Nikhil; Estrela, Pedro.

In: Current Topics in Medicinal Chemistry, Vol. 17, No. 22, 30.05.2017, p. 2470-2481.

Research output: Contribution to journalReview article

Bhalla, Nikhil ; Estrela, Pedro. / Biosensors for screening kinase inhibitors. In: Current Topics in Medicinal Chemistry. 2017 ; Vol. 17, No. 22. pp. 2470-2481.
@article{662837a0a2864a81861ae987f30ec74f,
title = "Biosensors for screening kinase inhibitors",
abstract = "For successful drug discovery it is important to understand the fundamentals of the underlying causes and consequences of the diseases for which the drug is being developed. One such physiological process in eukaryotic cells is protein phosphorylation, which is the main post-translational modification of proteins responsible for the onset or progression of Alzheimer's disease, diabetes and various cancers. Protein phosphorylation is facilitated by kinases and inhibitors of kinases act as drugs in controlling or curing these diseases by reducing protein phosphorylation. This review discusses the technologies capable of detecting kinase activity and screening candidate compounds to identify novel inhibitors of protein kinases.",
keywords = "Biosensors",
author = "Nikhil Bhalla and Pedro Estrela",
year = "2017",
month = "5",
day = "30",
doi = "10.2174/1568026617666170531113233",
language = "English",
volume = "17",
pages = "2470--2481",
journal = "Current Topics in Medicinal Chemistry",
issn = "1568-0266",
publisher = "Bentham Science Publishers B.V.",
number = "22",

}

TY - JOUR

T1 - Biosensors for screening kinase inhibitors

AU - Bhalla, Nikhil

AU - Estrela, Pedro

PY - 2017/5/30

Y1 - 2017/5/30

N2 - For successful drug discovery it is important to understand the fundamentals of the underlying causes and consequences of the diseases for which the drug is being developed. One such physiological process in eukaryotic cells is protein phosphorylation, which is the main post-translational modification of proteins responsible for the onset or progression of Alzheimer's disease, diabetes and various cancers. Protein phosphorylation is facilitated by kinases and inhibitors of kinases act as drugs in controlling or curing these diseases by reducing protein phosphorylation. This review discusses the technologies capable of detecting kinase activity and screening candidate compounds to identify novel inhibitors of protein kinases.

AB - For successful drug discovery it is important to understand the fundamentals of the underlying causes and consequences of the diseases for which the drug is being developed. One such physiological process in eukaryotic cells is protein phosphorylation, which is the main post-translational modification of proteins responsible for the onset or progression of Alzheimer's disease, diabetes and various cancers. Protein phosphorylation is facilitated by kinases and inhibitors of kinases act as drugs in controlling or curing these diseases by reducing protein phosphorylation. This review discusses the technologies capable of detecting kinase activity and screening candidate compounds to identify novel inhibitors of protein kinases.

KW - Biosensors

UR - https://doi.org/10.2174/1568026617666170531113233

U2 - 10.2174/1568026617666170531113233

DO - 10.2174/1568026617666170531113233

M3 - Review article

VL - 17

SP - 2470

EP - 2481

JO - Current Topics in Medicinal Chemistry

JF - Current Topics in Medicinal Chemistry

SN - 1568-0266

IS - 22

ER -