Bioreactor systems for tissue engineering: A four-dimensional challenge

M. Ellis, M. Jarman-Smith, J. B. Chaudhuri

Research output: Chapter or section in a book/report/conference proceedingChapter or section

22 Citations (SciVal)


The in vitro creation of three-dimensional tissues will require well-controlled culture tools to maximise nutrient mass transfer, allow the culture of multiple cell types, and assert mechanical forces on the cells. The development of bioreactor technologies will help greatly in this respect. Although still in its infancy, there are some basic design rules and general biological and physical considerations that we can integrate to create bioreactor systems that will manage the complex interactions that exist in tissue between individual cells, between cells and the matrix and cells and their environment. Furthermore, it is also becoming clear that a single bioreactor type will not be suitable to grow all tissue types. Bespoke bioreactor systems will be required for specific tissues or classes of tissue. This chapter has not detailed all of the issues related to tissue engineering bioreactors; its aim was to outline the key features that will contribute to the development of dynamic culture systems for the growth of human tissues. The following chapters in this book provide a source of knowledge on different aspects of bioreactor design and operation that we hope will provide a foundation for the future successful development of tissue engineering.

Original languageEnglish
Title of host publicationBioreactors for Tissue Engineering
Subtitle of host publicationPrinciples, Design and Operation
PublisherSpringer Netherlands
Number of pages18
ISBN (Print)1402037406, 9781402037405
Publication statusPublished - 1 Dec 2005

ASJC Scopus subject areas

  • General Engineering


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