Biomimetic flavin-catalyzed aldehyde oxidation

Alexander T. Murray; Pascal Matton; Nathan W. G. Fairhurst; Matthew P. John; David R. Carbery

doi:10.1021/ol301496m

Biomimetic flavin-catalyzed aldehyde oxidation

Alexander T. Murray
, Pascal Matton
, Nathan W. G. Fairhurst
, Matthew P. John
, David R. Carbery

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

61 Citations (SciVal)

428 Downloads (Pure)

Abstract

The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.

Original language	English
Pages (from-to)	3656-3659
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	14
Early online date	10 Jul 2012
DOIs	https://doi.org/10.1021/ol301496m
Publication status	Published - 20 Jul 2012

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10.1021/ol301496m

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This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol301496m
Accepted author manuscript, 553 KB

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title = "Biomimetic flavin-catalyzed aldehyde oxidation",

abstract = "The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35\% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.",

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AU - Murray, Alexander T.

AU - Matton, Pascal

AU - Fairhurst, Nathan W. G.

AU - John, Matthew P.

AU - Carbery, David R.

PY - 2012/7/20

Y1 - 2012/7/20

N2 - The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.

AB - The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.

UR - https://www.scopus.com/pages/publications/84864120528

UR - http://dx.doi.org/10.1021/ol301496m

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DO - 10.1021/ol301496m

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VL - 14

SP - 3656

EP - 3659

JO - Organic Letters

JF - Organic Letters

IS - 14

ER -

Biomimetic flavin-catalyzed aldehyde oxidation

Abstract

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