Biomimetic flavin-catalyzed aldehyde oxidation

Alexander T. Murray; Pascal Matton; Nathan W. G. Fairhurst; Matthew P. John; David R. Carbery

doi:10.1021/ol301496m

Biomimetic flavin-catalyzed aldehyde oxidation

Alexander T. Murray, Pascal Matton, Nathan W. G. Fairhurst, Matthew P. John, David R. Carbery

Department of Chemistry

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Abstract

The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.

Original language	English
Pages (from-to)	3656-3659
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	14
Early online date	10 Jul 2012
DOIs	https://doi.org/10.1021/ol301496m
Publication status	Published - 20 Jul 2012

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10.1021/ol301496m

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This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol301496m
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title = "Biomimetic flavin-catalyzed aldehyde oxidation",

abstract = "The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.",

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AU - Matton, Pascal

AU - Fairhurst, Nathan W. G.

AU - John, Matthew P.

AU - Carbery, David R.

PY - 2012/7/20

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N2 - The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.

AB - The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.

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JO - Organic Letters

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IS - 14

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Biomimetic flavin-catalyzed aldehyde oxidation

Abstract

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