Biomimetic flavin-catalyzed aldehyde oxidation

Alexander T. Murray, Pascal Matton, Nathan W. G. Fairhurst, Matthew P. John, David R. Carbery

Research output: Contribution to journalArticle

40 Citations (Scopus)
141 Downloads (Pure)

Abstract

The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.
Original languageEnglish
Pages (from-to)3656-3659
Number of pages4
JournalOrganic Letters
Volume14
Issue number14
Early online date10 Jul 2012
DOIs
Publication statusPublished - 20 Jul 2012

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    Murray, A. T., Matton, P., Fairhurst, N. W. G., John, M. P., & Carbery, D. R. (2012). Biomimetic flavin-catalyzed aldehyde oxidation. Organic Letters, 14(14), 3656-3659. https://doi.org/10.1021/ol301496m