Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data

Nadine Steckling, Alberto Gotti, Stephan Bose-O'Reilly, Dimitris Chapizanis, Danae Costopoulou, Frank De Vocht, Mercè Garí, Joan O. Grimalt, Ester Heath, Rosemary Hiscock, Marta Jagodic, Spyros P. Karakitsios, Kleopatra Kedikoglou, Tina Kosjek, Leondios Leondiadis, Thomas Maggos, Darja Mazej, Kinga Polańska, Andrew Povey, Joaquim Rovira & 10 others Julia Schoierer, Marta Schuhmacher, Zdravko Špirić, Anja Stajnko, Rob Stierum, Janja Snoj Tratnik, Irene Vassiliadou, Isabella Annesi-Maesano, Milena Horvat, Dimosthenis A. Sarigiannis

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Background: The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys – aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all pathways and sources. However, availability of specific biomarkers of exposure (BoE) is limited. Objectives: The objective was to summarize the availability of BoEs for a broad range of environmental stressors and exposure determinants and corresponding reference and exposure limit values and biomonitoring equivalents useful for unraveling the exposome using the framework of environment-wide association studies (EWAS). Methods: In a face-to-face group discussion, scope, content, and structure of the HEALS deliverable “Guidelines for appropriate BoE selection for EWAS studies” were determined. An expert-driven, distributed, narrative review process involving around 30 individuals of the HEALS consortium made it possible to include extensive information targeted towards the specific characteristics of various environmental stressors and exposure determinants. From the resulting 265 page report, targeted information about BoE, corresponding reference values (e.g., 95th percentile or measures of central tendency), exposure limit values (e.g., the German HBM I and II values) and biomonitoring equivalents (BEs) were summarized and updated. Results: 64 individual biological, chemical, physical, psychological and social environmental stressors or exposure determinants were included to fulfil the requirements of EWAS. The list of available BoEs is extensive with a number of 135; however, 12 of the stressors and exposure determinants considered do not leave any measurable specific substance in accessible body specimens. Opportunities to estimate the internal exposure stressors not (yet) detectable in human specimens were discussed. Conclusions: Data about internal exposures are useful to decode the exposome. The paper provides extensive information for EWAS. Information included serves as a guideline – snapshot in time without any claim to comprehensiveness – to interpret HBM data and offers opportunities to collect information about the internal exposure of stressors if no specific BoE is available.

Original languageEnglish
Pages (from-to)597-624
Number of pages28
JournalEnvironmental Research
Volume164
Early online date5 Apr 2018
DOIs
Publication statusPublished - 1 Jul 2018

Fingerprint

Environmental Monitoring
Biomarkers
biomonitoring
biomarker
Association reactions
Environmental Exposure
Availability
Guidelines
Health
European Union
exposure
Reference Values
Psychology
Population

Keywords

  • Biomarkers of exposure
  • Biomonitoring equivalents
  • Environment-wide association studies
  • Exposure limit values
  • Human biomonitoring
  • Reference values

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Steckling, N., Gotti, A., Bose-O'Reilly, S., Chapizanis, D., Costopoulou, D., De Vocht, F., ... Sarigiannis, D. A. (2018). Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data. Environmental Research, 164, 597-624. https://doi.org/10.1016/j.envres.2018.02.041

Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data. / Steckling, Nadine; Gotti, Alberto; Bose-O'Reilly, Stephan; Chapizanis, Dimitris; Costopoulou, Danae; De Vocht, Frank; Garí, Mercè; Grimalt, Joan O.; Heath, Ester; Hiscock, Rosemary; Jagodic, Marta; Karakitsios, Spyros P.; Kedikoglou, Kleopatra; Kosjek, Tina; Leondiadis, Leondios; Maggos, Thomas; Mazej, Darja; Polańska, Kinga; Povey, Andrew; Rovira, Joaquim; Schoierer, Julia; Schuhmacher, Marta; Špirić, Zdravko; Stajnko, Anja; Stierum, Rob; Tratnik, Janja Snoj; Vassiliadou, Irene; Annesi-Maesano, Isabella; Horvat, Milena; Sarigiannis, Dimosthenis A.

In: Environmental Research, Vol. 164, 01.07.2018, p. 597-624.

Research output: Contribution to journalReview article

Steckling, N, Gotti, A, Bose-O'Reilly, S, Chapizanis, D, Costopoulou, D, De Vocht, F, Garí, M, Grimalt, JO, Heath, E, Hiscock, R, Jagodic, M, Karakitsios, SP, Kedikoglou, K, Kosjek, T, Leondiadis, L, Maggos, T, Mazej, D, Polańska, K, Povey, A, Rovira, J, Schoierer, J, Schuhmacher, M, Špirić, Z, Stajnko, A, Stierum, R, Tratnik, JS, Vassiliadou, I, Annesi-Maesano, I, Horvat, M & Sarigiannis, DA 2018, 'Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data', Environmental Research, vol. 164, pp. 597-624. https://doi.org/10.1016/j.envres.2018.02.041
Steckling, Nadine ; Gotti, Alberto ; Bose-O'Reilly, Stephan ; Chapizanis, Dimitris ; Costopoulou, Danae ; De Vocht, Frank ; Garí, Mercè ; Grimalt, Joan O. ; Heath, Ester ; Hiscock, Rosemary ; Jagodic, Marta ; Karakitsios, Spyros P. ; Kedikoglou, Kleopatra ; Kosjek, Tina ; Leondiadis, Leondios ; Maggos, Thomas ; Mazej, Darja ; Polańska, Kinga ; Povey, Andrew ; Rovira, Joaquim ; Schoierer, Julia ; Schuhmacher, Marta ; Špirić, Zdravko ; Stajnko, Anja ; Stierum, Rob ; Tratnik, Janja Snoj ; Vassiliadou, Irene ; Annesi-Maesano, Isabella ; Horvat, Milena ; Sarigiannis, Dimosthenis A. / Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data. In: Environmental Research. 2018 ; Vol. 164. pp. 597-624.
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AU - Steckling, Nadine

AU - Gotti, Alberto

AU - Bose-O'Reilly, Stephan

AU - Chapizanis, Dimitris

AU - Costopoulou, Danae

AU - De Vocht, Frank

AU - Garí, Mercè

AU - Grimalt, Joan O.

AU - Heath, Ester

AU - Hiscock, Rosemary

AU - Jagodic, Marta

AU - Karakitsios, Spyros P.

AU - Kedikoglou, Kleopatra

AU - Kosjek, Tina

AU - Leondiadis, Leondios

AU - Maggos, Thomas

AU - Mazej, Darja

AU - Polańska, Kinga

AU - Povey, Andrew

AU - Rovira, Joaquim

AU - Schoierer, Julia

AU - Schuhmacher, Marta

AU - Špirić, Zdravko

AU - Stajnko, Anja

AU - Stierum, Rob

AU - Tratnik, Janja Snoj

AU - Vassiliadou, Irene

AU - Annesi-Maesano, Isabella

AU - Horvat, Milena

AU - Sarigiannis, Dimosthenis A.

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AB - Background: The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys – aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all pathways and sources. However, availability of specific biomarkers of exposure (BoE) is limited. Objectives: The objective was to summarize the availability of BoEs for a broad range of environmental stressors and exposure determinants and corresponding reference and exposure limit values and biomonitoring equivalents useful for unraveling the exposome using the framework of environment-wide association studies (EWAS). Methods: In a face-to-face group discussion, scope, content, and structure of the HEALS deliverable “Guidelines for appropriate BoE selection for EWAS studies” were determined. An expert-driven, distributed, narrative review process involving around 30 individuals of the HEALS consortium made it possible to include extensive information targeted towards the specific characteristics of various environmental stressors and exposure determinants. From the resulting 265 page report, targeted information about BoE, corresponding reference values (e.g., 95th percentile or measures of central tendency), exposure limit values (e.g., the German HBM I and II values) and biomonitoring equivalents (BEs) were summarized and updated. Results: 64 individual biological, chemical, physical, psychological and social environmental stressors or exposure determinants were included to fulfil the requirements of EWAS. The list of available BoEs is extensive with a number of 135; however, 12 of the stressors and exposure determinants considered do not leave any measurable specific substance in accessible body specimens. Opportunities to estimate the internal exposure stressors not (yet) detectable in human specimens were discussed. Conclusions: Data about internal exposures are useful to decode the exposome. The paper provides extensive information for EWAS. Information included serves as a guideline – snapshot in time without any claim to comprehensiveness – to interpret HBM data and offers opportunities to collect information about the internal exposure of stressors if no specific BoE is available.

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KW - Biomonitoring equivalents

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