Biomarkers of cardiometabolic health are associated with body composition characteristics but not physical activity in persons with spinal cord injury

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Abstract

OBJECTIVE: To examine (i) the associations between physical activity dimensions and physical characteristics (i.e. cardiorespiratory fitness and body composition) and, (ii) the associations between these variables and biomarkers of cardiometabolic health in persons with spinal cord injury (SCI). METHODS: A cross-sectional prospective cohort study with 7-day follow-up was conducted. Body composition, cardiorespiratory fitness and biomarkers of cardiometabolic health were measured in thirty-three participants with SCI (> 1 year post injury). Physical activity dimensions were objectively assessed over 7-days. RESULTS: Activity energy expenditure (r = .43), physical activity level (r = .39), and moderate-to-vigorous physical activity (MVPA) (r = .48) were significantly (P < 0.001) associated with absolute (L/min) peak oxygen uptake (V̇O2 peak). V̇O2 peak was significantly higher in persons performing ≥150 MVPA minutes/week compared to <40 minutes/week (P = 0.003). Individual physical activity dimensions were not significantly associated with biomarkers of cardiometabolic health. However, body composition characteristics (BMI, waist and hip circumference) showed significant (P < 0.04), moderate (r > .30) associations with parameters of metabolic regulation, lipid profiles and inflammatory biomarkers. Relative V̇O2 peak (ml/kg/min) was moderately associated with only insulin sensitivity (r = 0.37, P = 0.03). CONCLUSIONS: Physical activity dimensions are associated with cardiorespiratory fitness; however, stronger and more consistent associations suggest that poor cardiometabolic health is associated with higher body fat content. Given these findings, the regulation of energy balance should be an important consideration for researchers and clinicians looking to improve cardiometabolic health in persons with SCI.
Original languageEnglish
Pages (from-to)328-337
Number of pages10
JournalThe Journal of Spinal Cord Medicine
Volume42
Issue number3
Early online date13 Sep 2017
DOIs
Publication statusPublished - 2019

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Body Composition
Spinal Cord Injuries
Biomarkers
Health
Waist Circumference
Energy Metabolism
Insulin Resistance
Adipose Tissue
Hip
Cohort Studies
Research Personnel
Prospective Studies
Oxygen
Lipids
Wounds and Injuries
Cardiorespiratory Fitness

Keywords

  • Cardiorespiratory fitness
  • Cardiovascular disease
  • Metabolic disease
  • Paraplegia
  • Inflammation

Cite this

@article{29a6d8cbe8104aca83135ab16a90f50d,
title = "Biomarkers of cardiometabolic health are associated with body composition characteristics but not physical activity in persons with spinal cord injury",
abstract = "OBJECTIVE: To examine (i) the associations between physical activity dimensions and physical characteristics (i.e. cardiorespiratory fitness and body composition) and, (ii) the associations between these variables and biomarkers of cardiometabolic health in persons with spinal cord injury (SCI). METHODS: A cross-sectional prospective cohort study with 7-day follow-up was conducted. Body composition, cardiorespiratory fitness and biomarkers of cardiometabolic health were measured in thirty-three participants with SCI (> 1 year post injury). Physical activity dimensions were objectively assessed over 7-days. RESULTS: Activity energy expenditure (r = .43), physical activity level (r = .39), and moderate-to-vigorous physical activity (MVPA) (r = .48) were significantly (P < 0.001) associated with absolute (L/min) peak oxygen uptake (V̇O2 peak). V̇O2 peak was significantly higher in persons performing ≥150 MVPA minutes/week compared to <40 minutes/week (P = 0.003). Individual physical activity dimensions were not significantly associated with biomarkers of cardiometabolic health. However, body composition characteristics (BMI, waist and hip circumference) showed significant (P < 0.04), moderate (r > .30) associations with parameters of metabolic regulation, lipid profiles and inflammatory biomarkers. Relative V̇O2 peak (ml/kg/min) was moderately associated with only insulin sensitivity (r = 0.37, P = 0.03). CONCLUSIONS: Physical activity dimensions are associated with cardiorespiratory fitness; however, stronger and more consistent associations suggest that poor cardiometabolic health is associated with higher body fat content. Given these findings, the regulation of energy balance should be an important consideration for researchers and clinicians looking to improve cardiometabolic health in persons with SCI.",
keywords = "Cardiorespiratory fitness , Cardiovascular disease , Metabolic disease , Paraplegia , Inflammation",
author = "Tom Nightingale and Jean-Philippe Walhin and Dylan Thompson and James Bilzon",
year = "2019",
doi = "10.1080/10790268.2017.1368203",
language = "English",
volume = "42",
pages = "328--337",
journal = "The Journal of Spinal Cord Medicine",
issn = "1079-0268",
publisher = "Maney Publishing",
number = "3",

}

TY - JOUR

T1 - Biomarkers of cardiometabolic health are associated with body composition characteristics but not physical activity in persons with spinal cord injury

AU - Nightingale, Tom

AU - Walhin, Jean-Philippe

AU - Thompson, Dylan

AU - Bilzon, James

PY - 2019

Y1 - 2019

N2 - OBJECTIVE: To examine (i) the associations between physical activity dimensions and physical characteristics (i.e. cardiorespiratory fitness and body composition) and, (ii) the associations between these variables and biomarkers of cardiometabolic health in persons with spinal cord injury (SCI). METHODS: A cross-sectional prospective cohort study with 7-day follow-up was conducted. Body composition, cardiorespiratory fitness and biomarkers of cardiometabolic health were measured in thirty-three participants with SCI (> 1 year post injury). Physical activity dimensions were objectively assessed over 7-days. RESULTS: Activity energy expenditure (r = .43), physical activity level (r = .39), and moderate-to-vigorous physical activity (MVPA) (r = .48) were significantly (P < 0.001) associated with absolute (L/min) peak oxygen uptake (V̇O2 peak). V̇O2 peak was significantly higher in persons performing ≥150 MVPA minutes/week compared to <40 minutes/week (P = 0.003). Individual physical activity dimensions were not significantly associated with biomarkers of cardiometabolic health. However, body composition characteristics (BMI, waist and hip circumference) showed significant (P < 0.04), moderate (r > .30) associations with parameters of metabolic regulation, lipid profiles and inflammatory biomarkers. Relative V̇O2 peak (ml/kg/min) was moderately associated with only insulin sensitivity (r = 0.37, P = 0.03). CONCLUSIONS: Physical activity dimensions are associated with cardiorespiratory fitness; however, stronger and more consistent associations suggest that poor cardiometabolic health is associated with higher body fat content. Given these findings, the regulation of energy balance should be an important consideration for researchers and clinicians looking to improve cardiometabolic health in persons with SCI.

AB - OBJECTIVE: To examine (i) the associations between physical activity dimensions and physical characteristics (i.e. cardiorespiratory fitness and body composition) and, (ii) the associations between these variables and biomarkers of cardiometabolic health in persons with spinal cord injury (SCI). METHODS: A cross-sectional prospective cohort study with 7-day follow-up was conducted. Body composition, cardiorespiratory fitness and biomarkers of cardiometabolic health were measured in thirty-three participants with SCI (> 1 year post injury). Physical activity dimensions were objectively assessed over 7-days. RESULTS: Activity energy expenditure (r = .43), physical activity level (r = .39), and moderate-to-vigorous physical activity (MVPA) (r = .48) were significantly (P < 0.001) associated with absolute (L/min) peak oxygen uptake (V̇O2 peak). V̇O2 peak was significantly higher in persons performing ≥150 MVPA minutes/week compared to <40 minutes/week (P = 0.003). Individual physical activity dimensions were not significantly associated with biomarkers of cardiometabolic health. However, body composition characteristics (BMI, waist and hip circumference) showed significant (P < 0.04), moderate (r > .30) associations with parameters of metabolic regulation, lipid profiles and inflammatory biomarkers. Relative V̇O2 peak (ml/kg/min) was moderately associated with only insulin sensitivity (r = 0.37, P = 0.03). CONCLUSIONS: Physical activity dimensions are associated with cardiorespiratory fitness; however, stronger and more consistent associations suggest that poor cardiometabolic health is associated with higher body fat content. Given these findings, the regulation of energy balance should be an important consideration for researchers and clinicians looking to improve cardiometabolic health in persons with SCI.

KW - Cardiorespiratory fitness

KW - Cardiovascular disease

KW - Metabolic disease

KW - Paraplegia

KW - Inflammation

U2 - 10.1080/10790268.2017.1368203

DO - 10.1080/10790268.2017.1368203

M3 - Article

VL - 42

SP - 328

EP - 337

JO - The Journal of Spinal Cord Medicine

JF - The Journal of Spinal Cord Medicine

SN - 1079-0268

IS - 3

ER -