Biology and genome of a newly discovered sibling species of Caenorhabditis elegans

Natsumi Kanzaki; Isheng J. Tsai; Ryusei Tanaka; Vicky L. Hunt; Dang Liu; Kenji Tsuyama; Yasunobu Maeda; Satoshi Namai; Ryohei Kumagai; Alan Tracey; Nancy Holroyd; Stephen R. Doyle; Gavin C. Woodruff; Kazunori Murase; Hiromi Kitazume; Cynthia Chai; Allison Akagi; Oishika Panda; Huei Mien Ke; Frank C. Schroeder; John Wang; Matthew Berriman; Paul W. Sternberg; Asako Sugimoto; Taisei Kikuchi

doi:10.1038/s41467-018-05712-5

Biology and genome of a newly discovered sibling species of Caenorhabditis elegans

Natsumi Kanzaki, Isheng J. Tsai, Ryusei Tanaka, Vicky L. Hunt, Dang Liu, Kenji Tsuyama, Yasunobu Maeda, Satoshi Namai, Ryohei Kumagai, Alan Tracey, Nancy Holroyd, Stephen R. Doyle, Gavin C. Woodruff, Kazunori Murase, Hiromi Kitazume, Cynthia Chai, Allison Akagi, Oishika Panda, Huei Mien Ke, Frank C. SchroederJohn Wang, Matthew Berriman, Paul W. Sternberg, Asako Sugimoto, Taisei Kikuchi

Department of Life Sciences

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78 Citations (SciVal)

Abstract

A ‘sibling’ species of the model organism Caenorhabditis elegans has long been sought for use in comparative analyses that would enable deep evolutionary interpretations of biological phenomena. Here, we describe the first sibling species of C. elegans, C. inopinata n. sp., isolated from fig syconia in Okinawa, Japan. We investigate the morphology, developmental processes and behaviour of C. inopinata, which differ significantly from those of C. elegans. The 123-Mb C. inopinata genome was sequenced and assembled into six nuclear chromosomes, allowing delineation of Caenorhabditis genome evolution and revealing unique characteristics, such as highly expanded transposable elements that might have contributed to the genome evolution of C. inopinata. In addition, C. inopinata exhibits massive gene losses in chemoreceptor gene families, which could be correlated with its limited habitat area. We have developed genetic and molecular techniques for C. inopinata; thus C. inopinata provides an exciting new platform for comparative evolutionary studies.

Original language	English
Article number	3216
Journal	Nature Communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41467-018-05712-5
Publication status	Published - 10 Aug 2018

ASJC Scopus subject areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General Physics and Astronomy

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Kanzaki, N., Tsai, I. J., Tanaka, R., Hunt, V. L., Liu, D., Tsuyama, K., Maeda, Y., Namai, S., Kumagai, R., Tracey, A., Holroyd, N., Doyle, S. R., Woodruff, G. C., Murase, K., Kitazume, H., Chai, C., Akagi, A., Panda, O., Ke, H. M., ... Kikuchi, T. (2018). Biology and genome of a newly discovered sibling species of Caenorhabditis elegans. Nature Communications, 9(1), Article 3216. https://doi.org/10.1038/s41467-018-05712-5

Kanzaki, N, Tsai, IJ, Tanaka, R, Hunt, VL, Liu, D, Tsuyama, K, Maeda, Y, Namai, S, Kumagai, R, Tracey, A, Holroyd, N, Doyle, SR, Woodruff, GC, Murase, K, Kitazume, H, Chai, C, Akagi, A, Panda, O, Ke, HM, Schroeder, FC, Wang, J, Berriman, M, Sternberg, PW, Sugimoto, A & Kikuchi, T 2018, 'Biology and genome of a newly discovered sibling species of Caenorhabditis elegans', Nature Communications, vol. 9, no. 1, 3216. https://doi.org/10.1038/s41467-018-05712-5

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abstract = "A {\textquoteleft}sibling{\textquoteright} species of the model organism Caenorhabditis elegans has long been sought for use in comparative analyses that would enable deep evolutionary interpretations of biological phenomena. Here, we describe the first sibling species of C. elegans, C. inopinata n. sp., isolated from fig syconia in Okinawa, Japan. We investigate the morphology, developmental processes and behaviour of C. inopinata, which differ significantly from those of C. elegans. The 123-Mb C. inopinata genome was sequenced and assembled into six nuclear chromosomes, allowing delineation of Caenorhabditis genome evolution and revealing unique characteristics, such as highly expanded transposable elements that might have contributed to the genome evolution of C. inopinata. In addition, C. inopinata exhibits massive gene losses in chemoreceptor gene families, which could be correlated with its limited habitat area. We have developed genetic and molecular techniques for C. inopinata; thus C. inopinata provides an exciting new platform for comparative evolutionary studies.",

author = "Natsumi Kanzaki and Tsai, {Isheng J.} and Ryusei Tanaka and Hunt, {Vicky L.} and Dang Liu and Kenji Tsuyama and Yasunobu Maeda and Satoshi Namai and Ryohei Kumagai and Alan Tracey and Nancy Holroyd and Doyle, {Stephen R.} and Woodruff, {Gavin C.} and Kazunori Murase and Hiromi Kitazume and Cynthia Chai and Allison Akagi and Oishika Panda and Ke, {Huei Mien} and Schroeder, {Frank C.} and John Wang and Matthew Berriman and Sternberg, {Paul W.} and Asako Sugimoto and Taisei Kikuchi",

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AU - Panda, Oishika

AU - Ke, Huei Mien

AU - Schroeder, Frank C.

AU - Wang, John

AU - Berriman, Matthew

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Biology and genome of a newly discovered sibling species of Caenorhabditis elegans

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Vicky Hunt

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Biology and genome of a newly discovered sibling species of Caenorhabditis elegans

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