Biologic Agents in Psoriasis: British Association of Dermatologists' Guidelines for Biologic Intervention for Psoriasis 2009

C. H. Smith, A. V. Anstey, J. N.W.N. Barker, A. D. Burden, R. J.G. Chalmers, D. A. Chandler, A. Y. Finlay, C. E.M. Griffiths, K. Jackson, N. J. McHugh, K. E. McKenna, N. J. Reynolds, A. D. Ormerod

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Azathioprine has been available as an immunosuppressive agent for over 40 years, and current routine usage in dermatology is not restricted to licensed indications. Advances in understanding the metabolic fate of azathioprine have led to significant changes in prescribing practice and toxicity monitoring by U.K. dermatologists. The current state of knowledge concerning the use of azathioprine in dermatology is summarized, with identification of strength of evidence. Clinical indications and contraindications for azathioprine usage in dermatology are identified. Evidence-based recommendations are made for routine safety monitoring of patients treated with azathioprine, including pretreatment assessment of red blood cell thiopurine methyltransferase activity.

Original languageEnglish
Title of host publicationBritish Association of Dermatologists' Management Guidelines
EditorsN. H. Cox, J. S. C. English
PublisherWiley-Blackwell
Pages230-262
Number of pages33
ISBN (Print)9781444335521
DOIs
Publication statusPublished - 21 Mar 2011

ASJC Scopus subject areas

  • Medicine(all)

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    Smith, C. H., Anstey, A. V., Barker, J. N. W. N., Burden, A. D., Chalmers, R. J. G., Chandler, D. A., Finlay, A. Y., Griffiths, C. E. M., Jackson, K., McHugh, N. J., McKenna, K. E., Reynolds, N. J., & Ormerod, A. D. (2011). Biologic Agents in Psoriasis: British Association of Dermatologists' Guidelines for Biologic Intervention for Psoriasis 2009. In N. H. Cox, & J. S. C. English (Eds.), British Association of Dermatologists' Management Guidelines (pp. 230-262). Wiley-Blackwell. https://doi.org/10.1002/9781444329865.ch4