Biocatalytic dearomatisation of para-fluorobenzoic acid: Access to versatile homochiral building blocks with quaternary centres

Toby Nash, Scott Wharry, Thomas S. Moody, Simon Lewis

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Abstract

The enzyme benzoate dioxygenase (BZDO) from Ralstonia eutropha B9 is able to dihydroxylate benzoic acids in a dearomative process that proceeds with a different regioselectivity than other known dioxygenase enzymes. Here we show that 4-fluorobenzoic acid is oxidised by BZDO to give an enantiopure diol that can be rapidly elaborated to highly oxygenated homochiral building blocks with quaternary centres. Notably, the diol produced in this biotransformation displays reactivity which is distinct from that of the more extensively studied non-fluorinated analogue.
Original languageEnglish
Pages (from-to)90-94
Number of pages5
JournalChimica Oggi-Chemistry Today
Volume35
Issue number5
Publication statusPublished - 1 Oct 2017

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