Bio-Conjugated Advanced Materials for Targeted Disease Theranostics

Xi Le Hu, Nahyun Kwon, Kai Cheng Yan, Adam C. Sedgwick, Guo Rong Chen, Xiao Peng He, Tony D. James, Juyoung Yoon

Research output: Contribution to journalReview articlepeer-review

59 Citations (SciVal)


Human beings are “machines” that use endogenously produced biomolecules as “components” in signaling and for the maintenance of the body. These biomolecules consist of proteins, nucleic acids, and carbohydrates, which can either be extracted from biological substrates or synthesized by chemical/biochemical methods. These biomolecules have the ability to recognize/interact with other biomolecules that are overexpressed in disease cells. For targeted theranostics, strategies to chemically incorporate these natural biomolecules with advanced materials to treat human diseases by imaging-guided drug delivery or photodynamic/photothermal therapy are proposed, with improved biocompatibility. Herein, recent research on construction of quantum dots, nanoparticles, and 2D material platforms decorated with antibodies, peptides, nucleic acid aptamers, carbohydrates, and folic acid for targeted diagnosis and treatment are summarized and discussed. In addition, the various strategies required to construct effective functional materials for targeted cancer therapy are highlighted. The hope is that this review can inspire and guide those that are interested in the field of biomedicine to rationally design and develop new target-based theranostic materials.

Original languageEnglish
Article number1907906
JournalAdvanced Functional Materials
Issue number13
Early online date3 Feb 2020
Publication statusPublished - 24 Mar 2020

Bibliographical note

Funding Information:
X.-L.H. and N.K. contributed equally to this work. The authors thank the Natural Science Foundation of China (Nos. 21788102, 91853201, 21722801, and 21776078), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), The National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202) and the Shanghai Science and Technology Committee (No. 19410712600). J.Y. thanks the National Research Foundation of Korea (NRF), which was funded by the Korea government (MSIP) (No. 2012R1A3A2048814). T.D.J. thanks the Royal Society for a Wolfson Research Merit Award.

Publisher Copyright:
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


  • advanced materials
  • aptamers
  • biomolecules
  • peptides
  • theranostics

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics


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