Biased codon usage near intron-exon junctions: selection on splicing enhancers, splice-site recognition or something else?

J V Chamary, L D Hurst

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Two groups recently argued that, in human genes, synonymous sites near intron-exon junctions undergo selection for correct splicing. However, neither study controlled for the possibility of an underlying nucleotide bias at the ends of exons. In this article, we show that generalized A and T enrichment exists, which could be independent of splicing regulation. Evidence for selection between synonymous codons that are associated with splicing enhancers remains after controlling for this bias, whereas support for cryptic splice-site avoidance is diminished.
Original languageEnglish
Pages (from-to)256-259
Number of pages4
JournalTrends in Genetics
Volume21
Issue number5
DOIs
Publication statusPublished - 2005

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