Abstract
The suitability of using the selectivity factor, s, as a metric for kinetic resolution reactions and the errors associated with its measurement are considered. Investigation of the analytical error associated with HPLC analysis of a kinetic resolution reveals that one of the largest potential sources of variation arises from the ability of a practitioner to integrate the peaks from a single analysis. The consequences of this error on the reliability of reported s values are discussed, and some general rules for good practice regarding the use and reporting of s as a metric are suggested.
| Original language | English |
|---|---|
| Pages (from-to) | 5554-5560 |
| Number of pages | 7 |
| Journal | Tetrahedron |
| Volume | 74 |
| Issue number | 38 |
| Early online date | 25 May 2018 |
| DOIs | |
| Publication status | Published - 20 Sept 2018 |
Funding
The research leading to these results has received funding from the ERC under the European Union's Seventh Framework Programme ( FP7/2007--2013 )/E.R.C. grant agreement 279850. J.E.T. thanks The Leverhulme Trust [Early Career Fellowship ECF-2014-005 ] for financial support. A.D.S. thanks the Royal Society for a Wolfson Merit Award. Appendix A
Keywords
- Data analysis
- Error calculations
- HPLC analysis
- Kinetic resolution
- Selectivity factor
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry