Abstract
The suitability of using the selectivity factor, s, as a metric for kinetic resolution reactions and the errors associated with its measurement are considered. Investigation of the analytical error associated with HPLC analysis of a kinetic resolution reveals that one of the largest potential sources of variation arises from the ability of a practitioner to integrate the peaks from a single analysis. The consequences of this error on the reliability of reported s values are discussed, and some general rules for good practice regarding the use and reporting of s as a metric are suggested.
Original language | English |
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Pages (from-to) | 5554-5560 |
Number of pages | 7 |
Journal | Tetrahedron |
Volume | 74 |
Issue number | 38 |
Early online date | 25 May 2018 |
DOIs | |
Publication status | Published - 20 Sept 2018 |
Keywords
- Data analysis
- Error calculations
- HPLC analysis
- Kinetic resolution
- Selectivity factor
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry