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Abstract
Chromatin architecture has a significant impact on gene expression. Evidence in the last two decades support RNA as an important component of chromatin structure [Genes Dev. (2005) 19, 1635–1655; PLoS ONE (2007) 2, e1182; Nat. Genet. (2002) 30, 329–334]. Long non-coding RNAs (lncRNAs) are able to control chromatin structure through nucleosome positioning, interaction with chromatin re-modellers and chromosome looping. These functions are carried out in cis at the site of lncRNAs transcription or in trans at distant loci. While the evidence for a role in lncRNAs in regulating gene expression through chromatin interactions is increasing, there is still very little conclusive evidence for a potential role in looping organisation. Here, we review models for the involvement of lncRNAs in genome architecture and the experimental evidence to support them.
Original language | English |
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Pages (from-to) | 177-186 |
Number of pages | 10 |
Journal | Essays in Biochemistry |
Volume | 63 |
Issue number | 1 |
DOIs | |
Publication status | Published - 9 Apr 2019 |
Keywords
- Chromatin architecture
- Long non-coding RNA
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry
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Dive into the research topics of 'Being in a loop: how long non-coding RNAs organise genome architecture'. Together they form a unique fingerprint.Projects
- 1 Finished
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How Does the expression of One Gene Affect that of its Neighbour?
Murrell, A. (PI) & Hurst, L. (CoI)
1/01/17 → 28/02/21
Project: Research council