Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

Haobo Ge, Patrick J. Riss, Vincenzo Mirabello, David G. Calatayud, Stephen E. Flower, Rory L. Arrowsmith, Tim D. Fryer, Young Hong, Steve Sawiak, Robert M J Jacobs, Stanley W Botchway, Rex M. Tyrrell, Tony D. James, John S. Fossey, Jonathan R Dilworth, Franklin I. Aigbirhio, Sofia I. Pascu

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Abstract

Hybrid materials based on supramolecularly assembled single-walled carbon nanotubes (SWNTs) are generated for positron emission tomography (PET), magnetic resonance imaging, and fluorescence imaging. The all-in-one imaging probe allows quantitative imaging from subcellular resolution to whole tissue regions. The SWNTs can be exposed to aqueous solutions of non-radioactive and radioactive metal salts in the presence of fullerenes and β-d-glucan. Encapsulating 64Cu ions achieves a minimum of 69% incorporation of radiochemical. The results suggest that this method can be extended to other metal ions of medical relevance, such as zirconium(IV)-89 or rhenium(VII)-188, which are used for medical imaging or radiotherapy, respectively. The in vivo uptake of 64Cu(II)@SWNT@β-d-glucan in Wistar rats allows the investigation of organ biodistribution by microPET. Radioactivity rapidly accumulates predominantly in the lungs and myocardium with peak uptakes of 4.8 ± 0.9 standardized uptake value. Furthermore, such materials are fully traceable in cells by multiphoton fluorescence lifetime imaging with near-infrared excitation (910 nm).
LanguageEnglish
Pages437-460
Number of pages24
JournalChem
Volume3
Issue number3
Early online date31 Aug 2017
DOIs
StatusPublished - 14 Sep 2017

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Nanocapsules
Carbon Nanotubes
beta-Glucans
Carbon
Optical Imaging
Imaging techniques
Single-walled carbon nanotubes (SWCN)
carbon
fluorescence
Metals
Glucans
Ions
Rhenium
Fullerenes
fullerene
rhenium
ion
metal
Diagnostic Imaging
radioactivity

Cite this

Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo. / Ge, Haobo; Riss, Patrick J.; Mirabello, Vincenzo; Calatayud, David G.; Flower, Stephen E.; Arrowsmith, Rory L.; Fryer, Tim D.; Hong, Young; Sawiak, Steve; Jacobs, Robert M J; Botchway, Stanley W; Tyrrell, Rex M.; James, Tony D.; Fossey, John S.; Dilworth, Jonathan R; Aigbirhio, Franklin I.; Pascu, Sofia I.

In: Chem, Vol. 3, No. 3, 14.09.2017, p. 437-460.

Research output: Contribution to journalArticle

Ge, H, Riss, PJ, Mirabello, V, Calatayud, DG, Flower, SE, Arrowsmith, RL, Fryer, TD, Hong, Y, Sawiak, S, Jacobs, RMJ, Botchway, SW, Tyrrell, RM, James, TD, Fossey, JS, Dilworth, JR, Aigbirhio, FI & Pascu, SI 2017, 'Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo', Chem, vol. 3, no. 3, pp. 437-460. https://doi.org/10.1016/j.chempr.2017.06.013
Ge, Haobo ; Riss, Patrick J. ; Mirabello, Vincenzo ; Calatayud, David G. ; Flower, Stephen E. ; Arrowsmith, Rory L. ; Fryer, Tim D. ; Hong, Young ; Sawiak, Steve ; Jacobs, Robert M J ; Botchway, Stanley W ; Tyrrell, Rex M. ; James, Tony D. ; Fossey, John S. ; Dilworth, Jonathan R ; Aigbirhio, Franklin I. ; Pascu, Sofia I. / Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo. In: Chem. 2017 ; Vol. 3, No. 3. pp. 437-460.
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abstract = "Hybrid materials based on supramolecularly assembled single-walled carbon nanotubes (SWNTs) are generated for positron emission tomography (PET), magnetic resonance imaging, and fluorescence imaging. The all-in-one imaging probe allows quantitative imaging from subcellular resolution to whole tissue regions. The SWNTs can be exposed to aqueous solutions of non-radioactive and radioactive metal salts in the presence of fullerenes and β-d-glucan. Encapsulating 64Cu ions achieves a minimum of 69{\%} incorporation of radiochemical. The results suggest that this method can be extended to other metal ions of medical relevance, such as zirconium(IV)-89 or rhenium(VII)-188, which are used for medical imaging or radiotherapy, respectively. The in vivo uptake of 64Cu(II)@SWNT@β-d-glucan in Wistar rats allows the investigation of organ biodistribution by microPET. Radioactivity rapidly accumulates predominantly in the lungs and myocardium with peak uptakes of 4.8 ± 0.9 standardized uptake value. Furthermore, such materials are fully traceable in cells by multiphoton fluorescence lifetime imaging with near-infrared excitation (910 nm).",
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AU - Flower, Stephen E.

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AU - Botchway, Stanley W

AU - Tyrrell, Rex M.

AU - James, Tony D.

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