Bayesian determination of the effect of a deep eutectic solvent on the structure of lipid monolayers

Andrew McCluskey, Adrian Sanchez Fernandez, Karen Edler, Stephen Parker, Andrew J. Jackson, Richard A Campbell, Thomas Arnold

Research output: Contribution to journalArticle

Abstract

In this work, we present the first example of the self-assembly of phospholipid monolayers at the interface between air and an ionic solvent. Deep eutectic solvents are a novel class of environmentally friendly non-aqueous room temperature liquids with tunable properties, that have wide ranging potential applications and are capable of promoting the self-assembly of surfactant molecules. We use a chemically-consistent Bayesian modelling of X-ray and neutron reflectometry measurements to show that these monolayers broadly behave as they do on water. This method allows for the monolayer structure to be determined, alongside the molecular volumes of the individual monolayer components without the need for water-specific constraints to be introduced. Furthermore, using this method we are able to better understand the correlations present between parameters in the analytical model. This example of a non-aqueous phospholipid monolayer has important implications for the potential uses of these solvents and for our understanding of how biomolecules behave in the absence of water.
LanguageEnglish
JournalPhysical Chemistry Chemical Physics
DOIs
StatusPublished - 22 Feb 2019

Cite this

Bayesian determination of the effect of a deep eutectic solvent on the structure of lipid monolayers. / McCluskey, Andrew; Sanchez Fernandez, Adrian; Edler, Karen; Parker, Stephen; Jackson, Andrew J.; Campbell, Richard A; Arnold, Thomas.

In: Physical Chemistry Chemical Physics , 22.02.2019.

Research output: Contribution to journalArticle

McCluskey, Andrew ; Sanchez Fernandez, Adrian ; Edler, Karen ; Parker, Stephen ; Jackson, Andrew J. ; Campbell, Richard A ; Arnold, Thomas. / Bayesian determination of the effect of a deep eutectic solvent on the structure of lipid monolayers. In: Physical Chemistry Chemical Physics . 2019.
@article{19031b4fe34f4738ab99a143b9e2e0a3,
title = "Bayesian determination of the effect of a deep eutectic solvent on the structure of lipid monolayers",
abstract = "In this work, we present the first example of the self-assembly of phospholipid monolayers at the interface between air and an ionic solvent. Deep eutectic solvents are a novel class of environmentally friendly non-aqueous room temperature liquids with tunable properties, that have wide ranging potential applications and are capable of promoting the self-assembly of surfactant molecules. We use a chemically-consistent Bayesian modelling of X-ray and neutron reflectometry measurements to show that these monolayers broadly behave as they do on water. This method allows for the monolayer structure to be determined, alongside the molecular volumes of the individual monolayer components without the need for water-specific constraints to be introduced. Furthermore, using this method we are able to better understand the correlations present between parameters in the analytical model. This example of a non-aqueous phospholipid monolayer has important implications for the potential uses of these solvents and for our understanding of how biomolecules behave in the absence of water.",
author = "Andrew McCluskey and {Sanchez Fernandez}, Adrian and Karen Edler and Stephen Parker and Jackson, {Andrew J.} and Campbell, {Richard A} and Thomas Arnold",
year = "2019",
month = "2",
day = "22",
doi = "10.1039/C9CP00203K",
language = "English",
journal = "Physical Chemistry Chemical Physics",
issn = "1463-9076",
publisher = "Royal Society of Chemistry",

}

TY - JOUR

T1 - Bayesian determination of the effect of a deep eutectic solvent on the structure of lipid monolayers

AU - McCluskey, Andrew

AU - Sanchez Fernandez, Adrian

AU - Edler, Karen

AU - Parker, Stephen

AU - Jackson, Andrew J.

AU - Campbell, Richard A

AU - Arnold, Thomas

PY - 2019/2/22

Y1 - 2019/2/22

N2 - In this work, we present the first example of the self-assembly of phospholipid monolayers at the interface between air and an ionic solvent. Deep eutectic solvents are a novel class of environmentally friendly non-aqueous room temperature liquids with tunable properties, that have wide ranging potential applications and are capable of promoting the self-assembly of surfactant molecules. We use a chemically-consistent Bayesian modelling of X-ray and neutron reflectometry measurements to show that these monolayers broadly behave as they do on water. This method allows for the monolayer structure to be determined, alongside the molecular volumes of the individual monolayer components without the need for water-specific constraints to be introduced. Furthermore, using this method we are able to better understand the correlations present between parameters in the analytical model. This example of a non-aqueous phospholipid monolayer has important implications for the potential uses of these solvents and for our understanding of how biomolecules behave in the absence of water.

AB - In this work, we present the first example of the self-assembly of phospholipid monolayers at the interface between air and an ionic solvent. Deep eutectic solvents are a novel class of environmentally friendly non-aqueous room temperature liquids with tunable properties, that have wide ranging potential applications and are capable of promoting the self-assembly of surfactant molecules. We use a chemically-consistent Bayesian modelling of X-ray and neutron reflectometry measurements to show that these monolayers broadly behave as they do on water. This method allows for the monolayer structure to be determined, alongside the molecular volumes of the individual monolayer components without the need for water-specific constraints to be introduced. Furthermore, using this method we are able to better understand the correlations present between parameters in the analytical model. This example of a non-aqueous phospholipid monolayer has important implications for the potential uses of these solvents and for our understanding of how biomolecules behave in the absence of water.

U2 - 10.1039/C9CP00203K

DO - 10.1039/C9CP00203K

M3 - Article

JO - Physical Chemistry Chemical Physics

T2 - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

SN - 1463-9076

ER -