@inproceedings{d299f892bc4a41e2ab854926b4eff654,
title = "Basis for the use of rhDNase as a therapy in cystic fibrosis",
abstract = "To gauge the effect of nebulization on rhDNase, a clinical formulation of the protein was nebulized and samples were collected and analyzed by a number of analytical methods. Characterization of the aerodynamic profile of the aerosol was also performed. The ability of rhDNase as a therapeutic agent for the treatment of CF is dependent on its ability to hydrolyze the excessive amounts of DNA contained in the sputum of CF patients. The paper shows that hydrolysis of DNA leads to a drastic reduction in the viscoelastic properties of CF sputum. This reduction should, in turn, permit easier clearance of the airways, thus aiding the patient's ability to breathe. rhDNase was shown to be fully active after nebulization and its mode of action in reducing the viscoelastic properties of CF sputum was described.",
author = "Rodney Pearlman and Steven Shire and David Cipolla and Ann Daugherty and Tom Patapoff and Ross Clark and Gilbert Keller and Randy Mrsny",
year = "1992",
month = dec,
day = "31",
language = "English",
isbn = "0841222169",
series = "Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering",
publisher = "Publ by ACS",
pages = "222--223",
booktitle = "Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering",
}