Barrett's esophagus: Cancer and molecular biology

Michael K. Gibson , Arashinder S. Dhaliwal, Nicholas J. Clemons , Wayne A. Phillips, Katerina Dvorak, Daniel Tong , Simon Law, E. Daniel Pirchi , Jari Rasanen, Mark J. Krasna , Kaushal Parikh, Kausilia K. Krishnadath , Yu Chen, Leonard Griffiths, Benjamin J. Colleypriest, J. Mark Farrant, David Tosh, Kiron M. Das , Manisha Bajpai

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The following paper on the molecular biology of Barrett's esophagus (BE) includes commentaries on signaling pathways central to the development of BE including Hh, NF-κB, and IL-6/STAT3; surgical approaches for esophagectomy and classification of lesions by appropriate therapy; the debate over the merits of minimally invasive esophagectomy versus open surgery; outcomes for patients with pharyngolaryngoesophagectomy; the applications of neoadjuvant chemotherapy and chemoradiotherapy; animal models examining the surgical models of BE and esophageal adenocarcinoma; the roles of various morphogens and Cdx2 in BE; and the use of in vitro BE models for chemoprevention studies.
Original languageEnglish
Pages (from-to)296-314
Number of pages19
JournalAnnals of the New York Academy of Sciences
Volume1300
Issue number1
DOIs
Publication statusPublished - Oct 2013

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