Bacteriostatic activity of fluoro-analogues of 5-(2-hydroxyethyl)-4-methylthiazole, a metabolic intermediate in the biosynthesis of thiamine

Gordon Lowe; Barry Potter

doi:10.1039/P19800002026

Bacteriostatic activity of fluoro-analogues of 5-(2-hydroxyethyl)-4-methylthiazole, a metabolic intermediate in the biosynthesis of thiamine

Gordon Lowe, Barry Potter

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

2-Fluoro-5-(2-hydroxyethyl)-4-methylthiazole and 5-(2-fluoroethyl)-4-methylthiazole have been prepared and the latter converted into a fluoro-analogue of thiamine. All three compounds show bacteriostatic activity against E. coli.

Original language	English
Pages (from-to)	2026-2028
Journal	Journal of the Chemical Society: Perkin Transactions 1
Volume	1980
Issue number	0
DOIs	https://doi.org/10.1039/P19800002026
Publication status	Published - 1980

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10.1039/P19800002026

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title = "Bacteriostatic activity of fluoro-analogues of 5-(2-hydroxyethyl)-4-methylthiazole, a metabolic intermediate in the biosynthesis of thiamine",

abstract = "2-Fluoro-5-(2-hydroxyethyl)-4-methylthiazole and 5-(2-fluoroethyl)-4-methylthiazole have been prepared and the latter converted into a fluoro-analogue of thiamine. All three compounds show bacteriostatic activity against E. coli.",

author = "Gordon Lowe and Barry Potter",

year = "1980",

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N2 - 2-Fluoro-5-(2-hydroxyethyl)-4-methylthiazole and 5-(2-fluoroethyl)-4-methylthiazole have been prepared and the latter converted into a fluoro-analogue of thiamine. All three compounds show bacteriostatic activity against E. coli.

AB - 2-Fluoro-5-(2-hydroxyethyl)-4-methylthiazole and 5-(2-fluoroethyl)-4-methylthiazole have been prepared and the latter converted into a fluoro-analogue of thiamine. All three compounds show bacteriostatic activity against E. coli.

UR - http://dx.doi.org/10.1039/P19800002026

U2 - 10.1039/P19800002026

DO - 10.1039/P19800002026

M3 - Article

VL - 1980

SP - 2026

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JO - Journal of the Chemical Society: Perkin Transactions 1

JF - Journal of the Chemical Society: Perkin Transactions 1

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IS - 0

ER -

Bacteriostatic activity of fluoro-analogues of 5-(2-hydroxyethyl)-4-methylthiazole, a metabolic intermediate in the biosynthesis of thiamine

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