Bacteriostatic activity of fluoro-analogues of 5-(2-hydroxyethyl)-4-methylthiazole, a metabolic intermediate in the biosynthesis of thiamine

Gordon Lowe, Barry Potter

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Abstract

2-Fluoro-5-(2-hydroxyethyl)-4-methylthiazole and 5-(2-fluoroethyl)-4-methylthiazole have been prepared and the latter converted into a fluoro-analogue of thiamine. All three compounds show bacteriostatic activity against E. coli.
Original languageEnglish
Pages (from-to)2026-2028
JournalJournal of the Chemical Society: Perkin Transactions 1
Volume1980
Issue number0
DOIs
Publication statusPublished - 1980

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Thiamine
Biosynthesis
Escherichia coli
2-(4-methyl-1,3-thiazol-5-yl)ethanol
4-methylthiazole

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title = "Bacteriostatic activity of fluoro-analogues of 5-(2-hydroxyethyl)-4-methylthiazole, a metabolic intermediate in the biosynthesis of thiamine",
abstract = "2-Fluoro-5-(2-hydroxyethyl)-4-methylthiazole and 5-(2-fluoroethyl)-4-methylthiazole have been prepared and the latter converted into a fluoro-analogue of thiamine. All three compounds show bacteriostatic activity against E. coli.",
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AB - 2-Fluoro-5-(2-hydroxyethyl)-4-methylthiazole and 5-(2-fluoroethyl)-4-methylthiazole have been prepared and the latter converted into a fluoro-analogue of thiamine. All three compounds show bacteriostatic activity against E. coli.

UR - http://dx.doi.org/10.1039/P19800002026

U2 - 10.1039/P19800002026

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JO - Journal of the Chemical Society: Perkin Transactions 1

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