Azulene-A Bright Core for Sensing and Imaging

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Abstract

Azulene is a hydrocarbon isomer of naphthalene known for its unusual colour and fluorescence properties. Through the harnessing of these properties, the literature has been enriched with a series of chemical sensors and dosimeters with distinct colorimetric and fluorescence responses. This review focuses specifically on the latter of these phenomena. The review is subdivided into two sections. Section one discusses turn-on fluorescent sensors employing azulene, for which the literature is dominated by examples of the unusual phenomenon of azulene protonation-dependent fluorescence. Section two focuses on fluorescent azulenes that have been used in the context of biological sensing and imaging. To aid the reader, the azulene skeleton is highlighted in blue in each compound.

Original languageEnglish
Article number353
JournalMolecules (Basel, Switzerland)
Volume26
Issue number2
DOIs
Publication statusPublished - 12 Jan 2021

Keywords

  • azulene
  • bioimaging
  • chemodosimeter
  • chemosensor
  • dosimeter
  • fluorescence
  • sensor

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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