Azulene-A Bright Core for Sensing and Imaging

Lloyd C. Murfin, Simon E. Lewis

Research output: Contribution to journalReview articlepeer-review

31 Citations (SciVal)
123 Downloads (Pure)


Azulene is a hydrocarbon isomer of naphthalene known for its unusual colour and fluorescence properties. Through the harnessing of these properties, the literature has been enriched with a series of chemical sensors and dosimeters with distinct colorimetric and fluorescence responses. This review focuses specifically on the latter of these phenomena. The review is subdivided into two sections. Section one discusses turn-on fluorescent sensors employing azulene, for which the literature is dominated by examples of the unusual phenomenon of azulene protonation-dependent fluorescence. Section two focuses on fluorescent azulenes that have been used in the context of biological sensing and imaging. To aid the reader, the azulene skeleton is highlighted in blue in each compound.

Original languageEnglish
Article number353
JournalMolecules (Basel, Switzerland)
Issue number2
Publication statusPublished - 12 Jan 2021


  • azulene
  • bioimaging
  • chemodosimeter
  • chemosensor
  • dosimeter
  • fluorescence
  • sensor

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of 'Azulene-A Bright Core for Sensing and Imaging'. Together they form a unique fingerprint.

Cite this