Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome

J.L. Newton; J. Frith; D. Powell; K. Hackett; K. Wilton; S. Bowman; E. Price; C. Pease; J. Andrews; P. Emery; J. Hunter; M. Gupta; S. Vadivelu; I. Giles; D. Isenberg; P. Lanyon; A. Jones; M. Regan; A. Cooper; R. Moots; N. Sutcliffe; M. Bombardieri; C. Pitzalis; J. McLaren; S. Young-Min; B. Dasgupta; B. Griffiths; D. Lendrem; S. Mitchell; W.-F. Ng; E.C. Bacabac; R. Moots; K. Chadravarty; S. Lamabadusuriya; M. Bombardieri; C. Pitzalis; N. Sutcliffe; N. Gendi; R. Adeniba; J. Hamburger; A. Richards; S. Rauz; S. Brailsford; J. Logan; D. Mulherin; J. Andrews; P. Emery; A. McManus; C. Pease; A. Booth; M. Regan; T. Dimitroulas; L. Kadiki; D. Kaur; G. Kitas; M. Lloyd; L. Moore; E. Gordon; C. Lawson; M. Gupta; J. Hunter; L. Stirton; G. Ortiz; E. Price; G. Clunie; G. Rose; S. Cuckow; S. Knight; D. Symmons; B. Jones; A. Carr; S. Edgar; M. Carrozzo; F. Figuereido; H. Foggo; C. Gillespie; D. Lendrem; I. Macleod; S. Mitchell; J. Tarn; A. Jones; P. Lanyon; A. Muir; P. White; S. Young-Min; S. Pugmire; S. Vadivelu; A. Cooper; M. Watkins; A. Field; S. Kaye; D. Mewar; P. Medcalf; P. Tomlinson; D. Whiteside; N. McHugh; J. Pauling; J. James; N. Olaitan; M. Akil; J. McDermott; O. Godia; D. Coady; E. Kidd; L. Palmer; B. Dasgupta; V. Katsande; P. Long; U. Chandra; K. MacKay; S. Fedele; A. Ferenkeh-Koroma; D. Isenberg; H. Marconnell; S. Porter; P. Allcoat; J. McLaren

doi:10.1136/annrheumdis-2011-201009

Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome

J.L. Newton, J. Frith, D. Powell, K. Hackett, K. Wilton, S. Bowman, E. Price, C. Pease, J. Andrews, P. Emery, J. Hunter, M. Gupta, S. Vadivelu, I. Giles, D. Isenberg, P. Lanyon, A. Jones, M. Regan, A. Cooper, R. MootsN. Sutcliffe, M. Bombardieri, C. Pitzalis, J. McLaren, S. Young-Min, B. Dasgupta, B. Griffiths, D. Lendrem, S. Mitchell, W.-F. Ng, E.C. Bacabac, R. Moots, K. Chadravarty, S. Lamabadusuriya, M. Bombardieri, C. Pitzalis, N. Sutcliffe, N. Gendi, R. Adeniba, J. Hamburger, A. Richards, S. Rauz, S. Brailsford, J. Logan, D. Mulherin, J. Andrews, P. Emery, A. McManus, C. Pease, A. Booth, M. Regan, T. Dimitroulas, L. Kadiki, D. Kaur, G. Kitas, M. Lloyd, L. Moore, E. Gordon, C. Lawson, M. Gupta, J. Hunter, L. Stirton, G. Ortiz, E. Price, G. Clunie, G. Rose, S. Cuckow, S. Knight, D. Symmons, B. Jones, A. Carr, S. Edgar, M. Carrozzo, F. Figuereido, H. Foggo, C. Gillespie, D. Lendrem, I. Macleod, S. Mitchell, J. Tarn, A. Jones, P. Lanyon, A. Muir, P. White, S. Young-Min, S. Pugmire, S. Vadivelu, A. Cooper, M. Watkins, A. Field, S. Kaye, D. Mewar, P. Medcalf, P. Tomlinson, D. Whiteside, N. McHugh, J. Pauling, J. James, N. Olaitan, M. Akil, J. McDermott, O. Godia, D. Coady, E. Kidd, L. Palmer, B. Dasgupta, V. Katsande, P. Long, U. Chandra, K. MacKay, S. Fedele, A. Ferenkeh-Koroma, D. Isenberg, H. Marconnell, S. Porter, P. Allcoat, J. McLaren

Department of Life Sciences

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Abstract

Objectives: To determine the prevalence of autonomic dysfunction (dysautonomia) among patients with primary Sjögren's syndrome (PSS) and the relationships between dysautonomia and other clinical features of PSS. Methods: Multicentre, prospective, cross-sectional study of a UK cohort of 317 patients with clinically well-characterised PSS. Symptoms of autonomic dysfunction were assessed using a validated instrument, the Composite Autonomic Symptom Scale (COMPASS). The data were compared with an age- and sex-matched cohort of 317 community controls. The relationships between symptoms of dysautonomia and various clinical features of PSS were analysed using regression analysis. Results: COMPASS scores were significantly higher in patients with PSS than in age- and sex-matched community controls (median (IQR) 35.5 (20.9-46.0) vs 14.8 (4.4-30.2), p32.5, a cut-off value indicative of autonomic dysfunction. Furthermore, the COMPASS total score correlated independently with EULAR Sjögren's Syndrome Patient Reported Index (a composite measure of the overall burden of symptoms experienced by patients with PSS) (β=0.38, p

Original language	English
Pages (from-to)	1973-1979
Journal	Annals of the Rheumatic Diseases
Volume	71
Issue number	12
Early online date	5 May 2012
DOIs	https://doi.org/10.1136/annrheumdis-2011-201009
Publication status	Published - 2012

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Newton, J. L., Frith, J., Powell, D., Hackett, K., Wilton, K., Bowman, S., Price, E., Pease, C., Andrews, J., Emery, P., Hunter, J., Gupta, M., Vadivelu, S., Giles, I., Isenberg, D., Lanyon, P., Jones, A., Regan, M., Cooper, A., ... McLaren, J. (2012). Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome. Annals of the Rheumatic Diseases, 71(12), 1973-1979. https://doi.org/10.1136/annrheumdis-2011-201009

Newton, JL, Frith, J, Powell, D, Hackett, K, Wilton, K, Bowman, S, Price, E, Pease, C, Andrews, J, Emery, P, Hunter, J, Gupta, M, Vadivelu, S, Giles, I, Isenberg, D, Lanyon, P, Jones, A, Regan, M, Cooper, A, Moots, R, Sutcliffe, N, Bombardieri, M, Pitzalis, C, McLaren, J, Young-Min, S, Dasgupta, B, Griffiths, B, Lendrem, D, Mitchell, S, Ng, W-F, Bacabac, EC, Moots, R, Chadravarty, K, Lamabadusuriya, S, Bombardieri, M, Pitzalis, C, Sutcliffe, N, Gendi, N, Adeniba, R, Hamburger, J, Richards, A, Rauz, S, Brailsford, S, Logan, J, Mulherin, D, Andrews, J, Emery, P, McManus, A, Pease, C, Booth, A, Regan, M, Dimitroulas, T, Kadiki, L, Kaur, D, Kitas, G, Lloyd, M, Moore, L, Gordon, E, Lawson, C, Gupta, M, Hunter, J, Stirton, L, Ortiz, G, Price, E, Clunie, G, Rose, G, Cuckow, S, Knight, S, Symmons, D, Jones, B, Carr, A, Edgar, S, Carrozzo, M, Figuereido, F, Foggo, H, Gillespie, C, Lendrem, D, Macleod, I, Mitchell, S, Tarn, J, Jones, A, Lanyon, P, Muir, A, White, P, Young-Min, S, Pugmire, S, Vadivelu, S, Cooper, A, Watkins, M, Field, A, Kaye, S, Mewar, D, Medcalf, P, Tomlinson, P, Whiteside, D, McHugh, N, Pauling, J, James, J, Olaitan, N, Akil, M, McDermott, J, Godia, O, Coady, D, Kidd, E, Palmer, L, Dasgupta, B, Katsande, V, Long, P, Chandra, U, MacKay, K, Fedele, S, Ferenkeh-Koroma, A, Isenberg, D, Marconnell, H, Porter, S, Allcoat, P & McLaren, J 2012, 'Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome', Annals of the Rheumatic Diseases, vol. 71, no. 12, pp. 1973-1979. https://doi.org/10.1136/annrheumdis-2011-201009

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title = "Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sj{\"o}gren's syndrome",

abstract = "Objectives: To determine the prevalence of autonomic dysfunction (dysautonomia) among patients with primary Sj{\"o}gren's syndrome (PSS) and the relationships between dysautonomia and other clinical features of PSS. Methods: Multicentre, prospective, cross-sectional study of a UK cohort of 317 patients with clinically well-characterised PSS. Symptoms of autonomic dysfunction were assessed using a validated instrument, the Composite Autonomic Symptom Scale (COMPASS). The data were compared with an age- and sex-matched cohort of 317 community controls. The relationships between symptoms of dysautonomia and various clinical features of PSS were analysed using regression analysis. Results: COMPASS scores were significantly higher in patients with PSS than in age- and sex-matched community controls (median (IQR) 35.5 (20.9-46.0) vs 14.8 (4.4-30.2), p32.5, a cut-off value indicative of autonomic dysfunction. Furthermore, the COMPASS total score correlated independently with EULAR Sj{\"o}gren's Syndrome Patient Reported Index (a composite measure of the overall burden of symptoms experienced by patients with PSS) (β=0.38, p",

author = "J.L. Newton and J. Frith and D. Powell and K. Hackett and K. Wilton and S. Bowman and E. Price and C. Pease and J. Andrews and P. Emery and J. Hunter and M. Gupta and S. Vadivelu and I. Giles and D. Isenberg and P. Lanyon and A. Jones and M. Regan and A. Cooper and R. Moots and N. Sutcliffe and M. Bombardieri and C. Pitzalis and J. McLaren and S. Young-Min and B. Dasgupta and B. Griffiths and D. Lendrem and S. Mitchell and W.-F. Ng and E.C. Bacabac and R. Moots and K. Chadravarty and S. Lamabadusuriya and M. Bombardieri and C. Pitzalis and N. Sutcliffe and N. Gendi and R. Adeniba and J. Hamburger and A. Richards and S. Rauz and S. Brailsford and J. Logan and D. Mulherin and J. Andrews and P. Emery and A. McManus and C. Pease and A. Booth and M. Regan and T. Dimitroulas and L. Kadiki and D. Kaur and G. Kitas and M. Lloyd and L. Moore and E. Gordon and C. Lawson and M. Gupta and J. Hunter and L. Stirton and G. Ortiz and E. Price and G. Clunie and G. Rose and S. Cuckow and S. Knight and D. Symmons and B. Jones and A. Carr and S. Edgar and M. Carrozzo and F. Figuereido and H. Foggo and C. Gillespie and D. Lendrem and I. Macleod and S. Mitchell and J. Tarn and A. Jones and P. Lanyon and A. Muir and P. White and S. Young-Min and S. Pugmire and S. Vadivelu and A. Cooper and M. Watkins and A. Field and S. Kaye and D. Mewar and P. Medcalf and P. Tomlinson and D. Whiteside and N. McHugh and J. Pauling and J. James and N. Olaitan and M. Akil and J. McDermott and O. Godia and D. Coady and E. Kidd and L. Palmer and B. Dasgupta and V. Katsande and P. Long and U. Chandra and K. MacKay and S. Fedele and A. Ferenkeh-Koroma and D. Isenberg and H. Marconnell and S. Porter and P. Allcoat and J. McLaren",

year = "2012",

doi = "10.1136/annrheumdis-2011-201009",

language = "English",

volume = "71",

pages = "1973--1979",

journal = "Annals of the Rheumatic Diseases",

issn = "0003-4967",

publisher = "BMJ Publishing Group",

number = "12",

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TY - JOUR

T1 - Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome

AU - Newton, J.L.

AU - Frith, J.

AU - Powell, D.

AU - Hackett, K.

AU - Wilton, K.

AU - Bowman, S.

AU - Price, E.

AU - Pease, C.

AU - Andrews, J.

AU - Emery, P.

AU - Hunter, J.

AU - Gupta, M.

AU - Vadivelu, S.

AU - Giles, I.

AU - Isenberg, D.

AU - Lanyon, P.

AU - Jones, A.

AU - Regan, M.

AU - Cooper, A.

AU - Moots, R.

AU - Sutcliffe, N.

AU - Bombardieri, M.

AU - Pitzalis, C.

AU - McLaren, J.

AU - Young-Min, S.

AU - Dasgupta, B.

AU - Griffiths, B.

AU - Lendrem, D.

AU - Mitchell, S.

AU - Ng, W.-F.

AU - Bacabac, E.C.

AU - Moots, R.

AU - Chadravarty, K.

AU - Lamabadusuriya, S.

AU - Bombardieri, M.

AU - Pitzalis, C.

AU - Sutcliffe, N.

AU - Gendi, N.

AU - Adeniba, R.

AU - Hamburger, J.

AU - Richards, A.

AU - Rauz, S.

AU - Brailsford, S.

AU - Logan, J.

AU - Mulherin, D.

AU - Andrews, J.

AU - Emery, P.

AU - McManus, A.

AU - Pease, C.

AU - Booth, A.

AU - Regan, M.

AU - Dimitroulas, T.

AU - Kadiki, L.

AU - Kaur, D.

AU - Kitas, G.

AU - Lloyd, M.

AU - Moore, L.

AU - Gordon, E.

AU - Lawson, C.

AU - Gupta, M.

AU - Hunter, J.

AU - Stirton, L.

AU - Ortiz, G.

AU - Price, E.

AU - Clunie, G.

AU - Rose, G.

AU - Cuckow, S.

AU - Knight, S.

AU - Symmons, D.

AU - Jones, B.

AU - Carr, A.

AU - Edgar, S.

AU - Carrozzo, M.

AU - Figuereido, F.

AU - Foggo, H.

AU - Gillespie, C.

AU - Lendrem, D.

AU - Macleod, I.

AU - Mitchell, S.

AU - Tarn, J.

AU - Jones, A.

AU - Lanyon, P.

AU - Muir, A.

AU - White, P.

AU - Young-Min, S.

AU - Pugmire, S.

AU - Vadivelu, S.

AU - Cooper, A.

AU - Watkins, M.

AU - Field, A.

AU - Kaye, S.

AU - Mewar, D.

AU - Medcalf, P.

AU - Tomlinson, P.

AU - Whiteside, D.

AU - McHugh, N.

AU - Pauling, J.

AU - James, J.

AU - Olaitan, N.

AU - Akil, M.

AU - McDermott, J.

AU - Godia, O.

AU - Coady, D.

AU - Kidd, E.

AU - Palmer, L.

AU - Dasgupta, B.

AU - Katsande, V.

AU - Long, P.

AU - Chandra, U.

AU - MacKay, K.

AU - Fedele, S.

AU - Ferenkeh-Koroma, A.

AU - Isenberg, D.

AU - Marconnell, H.

AU - Porter, S.

AU - Allcoat, P.

AU - McLaren, J.

PY - 2012

Y1 - 2012

N2 - Objectives: To determine the prevalence of autonomic dysfunction (dysautonomia) among patients with primary Sjögren's syndrome (PSS) and the relationships between dysautonomia and other clinical features of PSS. Methods: Multicentre, prospective, cross-sectional study of a UK cohort of 317 patients with clinically well-characterised PSS. Symptoms of autonomic dysfunction were assessed using a validated instrument, the Composite Autonomic Symptom Scale (COMPASS). The data were compared with an age- and sex-matched cohort of 317 community controls. The relationships between symptoms of dysautonomia and various clinical features of PSS were analysed using regression analysis. Results: COMPASS scores were significantly higher in patients with PSS than in age- and sex-matched community controls (median (IQR) 35.5 (20.9-46.0) vs 14.8 (4.4-30.2), p32.5, a cut-off value indicative of autonomic dysfunction. Furthermore, the COMPASS total score correlated independently with EULAR Sjögren's Syndrome Patient Reported Index (a composite measure of the overall burden of symptoms experienced by patients with PSS) (β=0.38, p

AB - Objectives: To determine the prevalence of autonomic dysfunction (dysautonomia) among patients with primary Sjögren's syndrome (PSS) and the relationships between dysautonomia and other clinical features of PSS. Methods: Multicentre, prospective, cross-sectional study of a UK cohort of 317 patients with clinically well-characterised PSS. Symptoms of autonomic dysfunction were assessed using a validated instrument, the Composite Autonomic Symptom Scale (COMPASS). The data were compared with an age- and sex-matched cohort of 317 community controls. The relationships between symptoms of dysautonomia and various clinical features of PSS were analysed using regression analysis. Results: COMPASS scores were significantly higher in patients with PSS than in age- and sex-matched community controls (median (IQR) 35.5 (20.9-46.0) vs 14.8 (4.4-30.2), p32.5, a cut-off value indicative of autonomic dysfunction. Furthermore, the COMPASS total score correlated independently with EULAR Sjögren's Syndrome Patient Reported Index (a composite measure of the overall burden of symptoms experienced by patients with PSS) (β=0.38, p

UR - http://www.scopus.com/inward/record.url?scp=84860530494&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1136/annrheumdis-2011-201009

U2 - 10.1136/annrheumdis-2011-201009

DO - 10.1136/annrheumdis-2011-201009

M3 - Article

SN - 0003-4967

VL - 71

SP - 1973

EP - 1979

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

IS - 12

ER -

Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome

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