Autoantibodies in Raynaud’s Phenomenon

Victoria Flower

doi:10.1007/978-3-031-52581-0_13

Autoantibodies in Raynaud’s Phenomenon

Victoria Flower

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

Abstract

The identification of autoantibodies associated with Raynaud’s phenomenon (RP) provides intriguing insight into the relationship between autoimmunity and vascular function. RP is frequently the presenting symptom of autoimmune rheumatic disease, e.g. in systemic sclerosis (SSc). As such, autoantibodies can help identify RP patients who are at risk of progression to systemic disease and prompt appropriate monitoring. As well as being serological biomarkers, autoantibodies may directly contribute to the pathogenesis of vascular dysfunction. In this chapter, we shall discuss the various methods of autoantibody detection, their diagnostic and prognostic importance, and the potential contribution of autoantibodies in the pathogenesis of RP.

Original language	English
Title of host publication	Raynaud’s Phenomenon
Subtitle of host publication	From Pathogenesis to Management, Second Edition
Editors	F. M. Wigley, A. L. Herrick, N. A. Flavahan
Place of Publication	U. S. A.
Publisher	Springer Nature
Chapter	13
Pages	225-244
Number of pages	20
ISBN (Electronic)	9783031525810
ISBN (Print)	9783031525803, 978-3-031-52583-4
DOIs	https://doi.org/10.1007/978-3-031-52581-0_13
Publication status	Published - 3 May 2024

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-031-52581-0_13

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abstract = "The identification of autoantibodies associated with Raynaud{\textquoteright}s phenomenon (RP) provides intriguing insight into the relationship between autoimmunity and vascular function. RP is frequently the presenting symptom of autoimmune rheumatic disease, e.g. in systemic sclerosis (SSc). As such, autoantibodies can help identify RP patients who are at risk of progression to systemic disease and prompt appropriate monitoring. As well as being serological biomarkers, autoantibodies may directly contribute to the pathogenesis of vascular dysfunction. In this chapter, we shall discuss the various methods of autoantibody detection, their diagnostic and prognostic importance, and the potential contribution of autoantibodies in the pathogenesis of RP.",

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AB - The identification of autoantibodies associated with Raynaud’s phenomenon (RP) provides intriguing insight into the relationship between autoimmunity and vascular function. RP is frequently the presenting symptom of autoimmune rheumatic disease, e.g. in systemic sclerosis (SSc). As such, autoantibodies can help identify RP patients who are at risk of progression to systemic disease and prompt appropriate monitoring. As well as being serological biomarkers, autoantibodies may directly contribute to the pathogenesis of vascular dysfunction. In this chapter, we shall discuss the various methods of autoantibody detection, their diagnostic and prognostic importance, and the potential contribution of autoantibodies in the pathogenesis of RP.

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Autoantibodies in Raynaud’s Phenomenon

Abstract

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