Auto-Tandem Catalysis: Activation of Multiple, Mechanistically Distinct Process by a Single Catalyst.

A review. Auto-tandem catalysis (ATC) is a powerful method for the synthesis of heterocycles and carbocycles as well as acyclic compds. The process is defined as a single reagent catalyzing multiple, mechanistically distinct processes of a chem. reaction. In this review recent advances in ATC using transition metal catalysts is described. In particular, the use of different catalytic systems for the controlled synthesis of the desired product, enantioselective synthesizes in which multiple bonds are formed and mechanistic studies are illustrated with applications to the synthesis of heterocycles and carbocycles as well as acyclic compds. New approaches that use earth abundant catalysts, greener solvents or increased catalyst efficiency are highlighted. Examples of ATC reaction development are also included. In addn., ATC processes were used as key steps in the synthesis of natural products as well as biol. active compds. [on SciFinder(R)]