Author Correction: Structural insights into μ-opioid receptor activation (Nature, (2015), 524, 7565, (315-321), 10.1038/nature14886)

Weijiao Huang; Aashish Manglik; A. J. Venkatakrishnan; Toon Laeremans; Evan N. Feinberg; Adrian L. Sanborn; Hideaki E. Kato; Kathryn E. Livingston; Thor S. Thorsen; Ralf C. Kling; Sébastien Granier; Peter Gmeiner; Stephen M. Husbands; John R. Traynor; William I. Weis; Jan Steyaert; Ron O. Dror; Brian K. Kobilka

doi:10.1038/s41586-020-2542-z

Author Correction: Structural insights into μ-opioid receptor activation (Nature, (2015), 524, 7565, (315-321), 10.1038/nature14886)

Weijiao Huang, Aashish Manglik, A. J. Venkatakrishnan, Toon Laeremans, Evan N. Feinberg, Adrian L. Sanborn, Hideaki E. Kato, Kathryn E. Livingston, Thor S. Thorsen, Ralf C. Kling, Sébastien Granier, Peter Gmeiner, Stephen M. Husbands, John R. Traynor, William I. Weis, Jan Steyaert, Ron O. Dror, Brian K. Kobilka

Research output: Contribution to journal › Comment/debate › peer-review

4 Citations (SciVal)

Abstract

In this Article, the configuration of BU72 at the benzylic amine was mistakenly reported as (S). Re-fitting this stereocentre to (R) improved the fit of the observed density in the X-ray structure. The (S)-configuration was originally assigned on the basis of the expected stereochemistry from ref. 1. The origin of the inversion is unclear, but we propose that the original assignment, based only on nuclear Overhauser effect experiments, may well have been incorrect. We thank Thomas Munro for bringing this error to our attention. The Protein Data Bank (PDB) entry of the active μ-opoid receptor bound to the BU72 agonist has been updated as 5C1M. The original Article has not been corrected online.

Original language	English
Pages (from-to)	E16
Journal	Nature
Volume	584
Issue number	7820
DOIs	https://doi.org/10.1038/s41586-020-2542-z
Publication status	Published - 13 Aug 2020

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Huang, W., Manglik, A., Venkatakrishnan, A. J., Laeremans, T., Feinberg, E. N., Sanborn, A. L., Kato, H. E., Livingston, K. E., Thorsen, T. S., Kling, R. C., Granier, S., Gmeiner, P., Husbands, S. M., Traynor, J. R., Weis, W. I., Steyaert, J., Dror, R. O., & Kobilka, B. K. (2020). Author Correction: Structural insights into μ-opioid receptor activation (Nature, (2015), 524, 7565, (315-321), 10.1038/nature14886). Nature, 584(7820), E16. https://doi.org/10.1038/s41586-020-2542-z

Huang, W, Manglik, A, Venkatakrishnan, AJ, Laeremans, T, Feinberg, EN, Sanborn, AL, Kato, HE, Livingston, KE, Thorsen, TS, Kling, RC, Granier, S, Gmeiner, P, Husbands, SM, Traynor, JR, Weis, WI, Steyaert, J, Dror, RO & Kobilka, BK 2020, 'Author Correction: Structural insights into μ-opioid receptor activation (Nature, (2015), 524, 7565, (315-321), 10.1038/nature14886)', Nature, vol. 584, no. 7820, pp. E16. https://doi.org/10.1038/s41586-020-2542-z

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title = "Author Correction: Structural insights into μ-opioid receptor activation (Nature, (2015), 524, 7565, (315-321), 10.1038/nature14886)",

abstract = "In this Article, the configuration of BU72 at the benzylic amine was mistakenly reported as (S). Re-fitting this stereocentre to (R) improved the fit of the observed density in the X-ray structure. The (S)-configuration was originally assigned on the basis of the expected stereochemistry from ref. 1. The origin of the inversion is unclear, but we propose that the original assignment, based only on nuclear Overhauser effect experiments, may well have been incorrect. We thank Thomas Munro for bringing this error to our attention. The Protein Data Bank (PDB) entry of the active μ-opoid receptor bound to the BU72 agonist has been updated as 5C1M. The original Article has not been corrected online.",

author = "Weijiao Huang and Aashish Manglik and Venkatakrishnan, {A. J.} and Toon Laeremans and Feinberg, {Evan N.} and Sanborn, {Adrian L.} and Kato, {Hideaki E.} and Livingston, {Kathryn E.} and Thorsen, {Thor S.} and Kling, {Ralf C.} and S{\'e}bastien Granier and Peter Gmeiner and Husbands, {Stephen M.} and Traynor, {John R.} and Weis, {William I.} and Jan Steyaert and Dror, {Ron O.} and Kobilka, {Brian K.}",

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T2 - Structural insights into μ-opioid receptor activation (Nature, (2015), 524, 7565, (315-321), 10.1038/nature14886)

AU - Huang, Weijiao

AU - Manglik, Aashish

AU - Venkatakrishnan, A. J.

AU - Laeremans, Toon

AU - Feinberg, Evan N.

AU - Sanborn, Adrian L.

AU - Kato, Hideaki E.

AU - Livingston, Kathryn E.

AU - Thorsen, Thor S.

AU - Kling, Ralf C.

AU - Granier, Sébastien

AU - Gmeiner, Peter

AU - Husbands, Stephen M.

AU - Traynor, John R.

AU - Weis, William I.

AU - Steyaert, Jan

AU - Dror, Ron O.

AU - Kobilka, Brian K.

PY - 2020/8/13

Y1 - 2020/8/13

N2 - In this Article, the configuration of BU72 at the benzylic amine was mistakenly reported as (S). Re-fitting this stereocentre to (R) improved the fit of the observed density in the X-ray structure. The (S)-configuration was originally assigned on the basis of the expected stereochemistry from ref. 1. The origin of the inversion is unclear, but we propose that the original assignment, based only on nuclear Overhauser effect experiments, may well have been incorrect. We thank Thomas Munro for bringing this error to our attention. The Protein Data Bank (PDB) entry of the active μ-opoid receptor bound to the BU72 agonist has been updated as 5C1M. The original Article has not been corrected online.

AB - In this Article, the configuration of BU72 at the benzylic amine was mistakenly reported as (S). Re-fitting this stereocentre to (R) improved the fit of the observed density in the X-ray structure. The (S)-configuration was originally assigned on the basis of the expected stereochemistry from ref. 1. The origin of the inversion is unclear, but we propose that the original assignment, based only on nuclear Overhauser effect experiments, may well have been incorrect. We thank Thomas Munro for bringing this error to our attention. The Protein Data Bank (PDB) entry of the active μ-opoid receptor bound to the BU72 agonist has been updated as 5C1M. The original Article has not been corrected online.

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DO - 10.1038/s41586-020-2542-z

M3 - Comment/debate

AN - SCOPUS:85088600219

SN - 0028-0836

VL - 584

SP - E16

JO - Nature

JF - Nature

IS - 7820

ER -

Author Correction: Structural insights into μ-opioid receptor activation (Nature, (2015), 524, 7565, (315-321), 10.1038/nature14886)

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