TY - JOUR
T1 - Atypical Development of Attentional Control Associates with Later Adaptive Functioning, Autism and ADHD Traits
AU - Team, the Eurosibs
AU - Hendry, Alexandra
AU - Jones, Emily J.H.
AU - Bedford, Rachael
AU - Andersson Konke, Linn
AU - Begum Ali, Jannath
AU - Bӧlte, Sven
AU - Brocki, Karin C.
AU - Demurie, Ellen
AU - Johnson, Mark
AU - Pijl, Mirjam K.J.
AU - Roeyers, Herbert
AU - Charman, Tony
AU - Achermann, Sheila
AU - Agyapong, Mary
AU - Astenvald, Rebecka
AU - Axelson, Lisa
AU - Bazelmans, Tessel
AU - Blommers, Karlijn
AU - Bontinck, Chloè
AU - van den Boomen, Carlijn
AU - Boterberg, Sofie
AU - Braukmann, Ricarda
AU - de Bruijn, Yvette
AU - Bruyneel, Eva
AU - Buitelaar, Jan K.
AU - Dafner, Leila
AU - Darki, Fahime
AU - Davies, Kim
AU - Ersoy, Mutluhan
AU - Falck-Ytter, Terje
AU - Fernandes, Janice
AU - Freeman, Zoë
AU - Gliga, Teea
AU - Gredebäck, Gustaf
AU - Greensmith, Marian
AU - Haartsen, Rianne
AU - van Ierland-Veerhoek, Sanne
AU - de Jonge, Maretha V.
AU - Kalwarowsky, Sarah
AU - Kemner, Chantal
AU - Kolesnik, Anna
AU - de Korte, Manon
AU - Lundin-Kleberg, Johan
AU - Munsters, Nicolette M.
AU - Nyström, Pär
AU - Pasco, Greg
AU - Pirazzoli, Laura
AU - Ristolainen, Johanna
AU - Stadin, Andrietta
AU - Taylor, Chloë
N1 - Funding Information:
We would like to thank all the families who participated in the Babystudie, British Autism Study of Infant Siblings (BASIS), Studying Autism and ADHD Risks (STAARS), Sisters And Brothers of Children with Autism (ZEBRA) and Early Autism Sweden (EASE) projects. We would also like to acknowledge the project funders, as follows: Babystudie: funded by the Research Foundation Flanders, Ghent University Special Research Fund and the Support Fund Marguerite-Marie Delacroix; BASIS: Funded by MRC Programme [grant numbers G0701484 and MR/K021389/1], the BASIS funding consortium led by Autistica ( www.basisnetwork.org ), Autism Speaks, EC FP7 (EU-AIMS Innovative Medicines Initiative joint undertaking grant agreement number 115300, resources of which are composed of financial contributions from the European Union’s Seventh Framework Programme, Autism Speaks and EFPIA companies’ in-kind contribution) and EC (AIMS-2-TRIALS Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777394. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA and Autism Speaks, Autistica, SFARI); EASE: funded by Riksbankens Jubileumsfond (Dnr. NHS14-1802:1); ZEBRA: funded by Netherlands Organization for Scientific Research (NWO) VICI grant n° 45307004, and the K.F. Hein Fonds. A. Hendry was supported by an ESRC Postdoctoral Fellowship (ES/S011730/1) and by the Scott Family Junior Research Fellowship in Autism (University College Oxford). R. Bedford was supported by a Sir Henry Wellcome Postdoctoral Fellowship (103046/Z/13/Z) and a King’s Prize Fellowship (204823/Z/16/Z). This research was also supported by a UK Medical Research Council Programme Grant (MR/K021389/1) and the Marie Sklodowska Curie Actions of the European Community’s Horizon 2020 Program under grant agreement no. 642996 (Brainview).
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/11/30
Y1 - 2020/11/30
N2 - Autism is frequently associated with difficulties with top-down attentional control, which impact on individuals’ mental health and quality of life. The developmental processes involved in these attentional difficulties are not well understood. Using a data-driven approach, 2 samples (N = 294 and 412) of infants at elevated and typical likelihood of autism were grouped according to profiles of parent report of attention at 10, 15 and 25 months. In contrast to the normative profile of increases in attentional control scores between infancy and toddlerhood, a minority (7–9%) showed plateauing attentional control scores between 10 and 25 months. Consistent with pre-registered hypotheses, plateaued growth of attentional control was associated with elevated autism and ADHD traits, and lower adaptive functioning at age 3 years.
AB - Autism is frequently associated with difficulties with top-down attentional control, which impact on individuals’ mental health and quality of life. The developmental processes involved in these attentional difficulties are not well understood. Using a data-driven approach, 2 samples (N = 294 and 412) of infants at elevated and typical likelihood of autism were grouped according to profiles of parent report of attention at 10, 15 and 25 months. In contrast to the normative profile of increases in attentional control scores between infancy and toddlerhood, a minority (7–9%) showed plateauing attentional control scores between 10 and 25 months. Consistent with pre-registered hypotheses, plateaued growth of attentional control was associated with elevated autism and ADHD traits, and lower adaptive functioning at age 3 years.
KW - ADHD
KW - Attention
KW - Atypical development
KW - Autism
KW - Infant
KW - Intermediate phenotype
UR - http://www.scopus.com/inward/record.url?scp=85082977397&partnerID=8YFLogxK
U2 - 10.1007/s10803-020-04465-9
DO - 10.1007/s10803-020-04465-9
M3 - Article
SN - 0162-3257
VL - 50
SP - 4085
EP - 4105
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
ER -
