Asymmetric synthesis of chiral delta-lactones containing multiple contiguous stereocenters

Jennifer Peed, I P Dominguez, Iwan R Davies, M Cheeseman, James E Taylor, Gabriele Kociok-Kohn, Steven D Bull

Research output: Contribution to journalArticle

11 Citations (Scopus)
78 Downloads (Pure)

Abstract

A versatile methodology for the asymmetric synthesis of chiral delta-lactones containing multiple contiguous stereocenters has been developed that relies on a series of Evans' aldol, hydroxyl-directed cyclopropanation, methanolysis, and Hg(II) mediated cyclopropane ring-opening reactions for stereocontrol.
Original languageEnglish
Pages (from-to)3592-3595
Number of pages4
JournalOrganic Letters
Volume13
Issue number14
DOIs
Publication statusPublished - 15 Jul 2011

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