Asymmetric Dearomatization Under Enzymatic Conditions

Research output: Chapter or section in a book/report/conference proceedingChapter or section


This chapter summarizes the state of the art in biocatalytic arene dearomatization. Overwhelmingly, this is carried out oxidatively, with formation of dearomatized cyclohexadiene-diols (so-called arene cis-diols) being the field in which the most extensive progress has been made. The dearomatized substances produced in this way are versatile chiral pool starting materials for synthesis, and they have been employed in total syntheses of many classes of natural products, as well as of nonnatural targets of industrial relevance. The known arene cis-diols are tabulated for easy reference and guidance is given on how to obtain arene cis-diols.
Original languageEnglish
Title of host publicationAsymmetric Dearomatization Reactions
EditorsShu-Li You
Number of pages67
ISBN (Electronic)9783527698479
ISBN (Print)9783527338511
Publication statusPublished - 24 Jun 2016


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