Associations of erosive arthritis with anti-cyclic citrullinated peptide antibodies and MHC Class II alleles in systemic lupus erythematosus.

Madelynn T Chan, Patricia Owen, Juliet Dunphy, Beverley Cox, Charlotte Carmichael, Eleanor Korendowych, Neil J McHugh

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Abstract

The frequency of EA in SLE is likely to be higher than previously reported. Anti-CCP+ patients with SLE are more likely to have EA. Anti-CCP may be a useful serological marker for EA for patients presenting with synovitis. Anti-citrulline antibodies may have a pathogenic role in the development of major erosions, resulting in clinical features that overlap SLE with RA (rhupus).
Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalJournal of Rheumatology
Volume35
Issue number1
Publication statusPublished - 2008

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