Association of genetic liability to smoking initiation with e-cigarette use in young adults: A cohort study

Jasmine N. Khouja; Robyn E. Wootton; Amy E. Taylor; George Davey Smith; Marcus R. Munafò

Association of genetic liability to smoking initiation with e-cigarette use in young adults: A cohort study

Jasmine N. Khouja
, Robyn E. Wootton
, Amy E. Taylor
, George Davey Smith
, Marcus R. Munafò

Vice Chancellor's Office

MRC Integrative Epidemiology Unit
University of Bristol
University Hospitals Bristol NHS Foundation Trust

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

Abstract

This chapter explores the association between smoking initiation PRS and e-cigarette use, using logistic regression. The use of e-cigarettes for smoking cessation is common among young adults in the United Kingdom; therefore, it would be logical to assume that smoking causally influences e-cigarette use in this population. Ethics approval for the study was obtained from the ALSPAC Ethics and Law Committee and the Local Research Ethics Committees. Consent for biological samples has been collected in accordance with the Human Tissue Act. Four negative control outcomes at age 23 and 24 were included in the analysis: high number of sexual partners, having been in trouble with the law, ever gambling, and enjoying taking risks. Self-reported smoking and e-cigarette use were associated with lower parental SEP and having externalising disorders in childhood. Self-reported smoking and e-cigarette use were also associated with increased odds of engaging in risk-taking behaviours.

Original language	English
Title of host publication	Advances in Surgical and Medical Specialties
Editors	Raj Bawa
Place of Publication	Singapore
Publisher	Jenny Stanford Publishing
Chapter	44
Pages	945-963
Number of pages	19
ISBN (Electronic)	9781000602746
ISBN (Print)	9789814877459
Publication status	Published - 14 Jul 2023

Keywords

Attention-deficit/hyperactivity disorder (ADHD)
Conduct disorder (CD)
Development and wellbeing assessment (DAWBA)
Electronic cigarette (e-cigarette)
Genome-wide association studies (GWAS)
Horizontal pleiotropy
Hyperactivity
Instrument strength independent of direct effect (InSIDE)
Mendelian randomization (MR)
Minor allele frequency (MAF)
Negative control
Odds ratio (OR)
Oppositional defiant disorder (ODD)
Polygenic risk scores (PRS)
Single nucleotide polymorphisms (SNPs)
Socioeconomic position (SEP)
Standard deviation (SD)
Strengthening the reporting of observational studies in epidemiology (STROBE)
Strengths and difficulties questionnaire (SDQ)
Vertical pleiotropy

ASJC Scopus subject areas

General Nursing
General Medicine
General Engineering
General Biochemistry,Genetics and Molecular Biology

Access to Document

https://www.taylorfrancis.com/chapters/edit/10.1201/9781003298304-44

Cite this

Association of genetic liability to smoking initiation with e-cigarette use in young adults: A cohort study. / Khouja, Jasmine N.; Wootton, Robyn E.; Taylor, Amy E. et al.
Advances in Surgical and Medical Specialties. ed. / Raj Bawa. Singapore: Jenny Stanford Publishing, 2023. p. 945-963.

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

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abstract = "This chapter explores the association between smoking initiation PRS and e-cigarette use, using logistic regression. The use of e-cigarettes for smoking cessation is common among young adults in the United Kingdom; therefore, it would be logical to assume that smoking causally influences e-cigarette use in this population. Ethics approval for the study was obtained from the ALSPAC Ethics and Law Committee and the Local Research Ethics Committees. Consent for biological samples has been collected in accordance with the Human Tissue Act. Four negative control outcomes at age 23 and 24 were included in the analysis: high number of sexual partners, having been in trouble with the law, ever gambling, and enjoying taking risks. Self-reported smoking and e-cigarette use were associated with lower parental SEP and having externalising disorders in childhood. Self-reported smoking and e-cigarette use were also associated with increased odds of engaging in risk-taking behaviours.",

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AB - This chapter explores the association between smoking initiation PRS and e-cigarette use, using logistic regression. The use of e-cigarettes for smoking cessation is common among young adults in the United Kingdom; therefore, it would be logical to assume that smoking causally influences e-cigarette use in this population. Ethics approval for the study was obtained from the ALSPAC Ethics and Law Committee and the Local Research Ethics Committees. Consent for biological samples has been collected in accordance with the Human Tissue Act. Four negative control outcomes at age 23 and 24 were included in the analysis: high number of sexual partners, having been in trouble with the law, ever gambling, and enjoying taking risks. Self-reported smoking and e-cigarette use were associated with lower parental SEP and having externalising disorders in childhood. Self-reported smoking and e-cigarette use were also associated with increased odds of engaging in risk-taking behaviours.

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KW - Development and wellbeing assessment (DAWBA)

KW - Electronic cigarette (e-cigarette)

KW - Genome-wide association studies (GWAS)

KW - Horizontal pleiotropy

KW - Hyperactivity

KW - Instrument strength independent of direct effect (InSIDE)

KW - Mendelian randomization (MR)

KW - Minor allele frequency (MAF)

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KW - Odds ratio (OR)

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KW - Polygenic risk scores (PRS)

KW - Single nucleotide polymorphisms (SNPs)

KW - Socioeconomic position (SEP)

KW - Standard deviation (SD)

KW - Strengthening the reporting of observational studies in epidemiology (STROBE)

KW - Strengths and difficulties questionnaire (SDQ)

KW - Vertical pleiotropy

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BT - Advances in Surgical and Medical Specialties

A2 - Bawa, Raj

PB - Jenny Stanford Publishing

CY - Singapore

ER -

Association of genetic liability to smoking initiation with e-cigarette use in young adults: A cohort study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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