Asking the Right Questions: What Can the Structure of the CCN Protein Domains Tell Us?

Kenneth P Holbourn, B Perbal, K Ravi Acharya

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

CCN proteins are modular multifunctional proteins comprised of four discrete domains: (1) an IGFBP domain, (2) a VWC domain, (3) a TSP domain, and (4) a CT domain. These domains give a broad repertoire of functions to the CCN family including angiogenesis, skeletal development tumourigenesis, wound healing, cell proliferation, adhesion and survival. These wide variety of biological functions are enabled due to the multi-domain nature of the protein allowing interactions with an extensive range of ligands and effectors and the possibility of multiple domains acting in concert. A closer look at each domain from a biological and structural perspective could give insights into their function.
Original languageEnglish
Title of host publicationCCN Proteins in Health and Disease: An Overview of the Fifth International Workshop on the CCN Family of Genes
EditorsA. Perbal, M. Takigawa , B. Perbal
Place of PublicationDordrecht
PublisherSpringer
Pages15-40
Number of pages26
ISBN (Electronic)978-90-481-3779-4
ISBN (Print)978-90-481-3778-7
DOIs
Publication statusPublished - 2010
Event5th International Workshop on the CCN Family of Genes - Toronto, Canada
Duration: 18 Oct 200822 Oct 2008

Publication series

NameCCN Proteins in Health and Disease

Conference

Conference5th International Workshop on the CCN Family of Genes
CountryCanada
CityToronto
Period18/10/0822/10/08

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  • Cite this

    Holbourn, K. P., Perbal, B., & Acharya, K. R. (2010). Asking the Right Questions: What Can the Structure of the CCN Protein Domains Tell Us? In A. Perbal, M. Takigawa , & B. Perbal (Eds.), CCN Proteins in Health and Disease: An Overview of the Fifth International Workshop on the CCN Family of Genes (pp. 15-40). (CCN Proteins in Health and Disease). Springer. https://doi.org/10.1007/978-90-481-3779-4_3