Arylboronic Acid Catalyzed C-Alkylation and Allylation Reactions Using Benzylic Alcohols

Susana Estopina-Duran, Euan Mclean, Liam Donnelly, Bryony Hockin, James Taylor

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The arylboronic acid catalyzed dehydrative C-alkylation of 1,3-diketones and 1,3-ketoesters using secondary benzylic alcohols as the electrophile is reported, forming new C–C bonds (19 examples, up to 98% yield) with the release of water as the only byproduct. The process is also applicable to the allylation of benzylic alcohols using allyltrimethylsilane as the nucleophile (12 examples, up to 96% yield).

Original languageEnglish
Pages (from-to)7547-7551
JournalOrganic Letters
Volume22
Issue number19
Early online date22 Sep 2020
DOIs
Publication statusPublished - 2 Oct 2020

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