Artificial Intelligence as a Diagnostic Tool in Non-Invasive Imaging in the Assessment of Coronary Artery Disease

Gemina Doolub, Michail Mamalakis, Samer Alabed, Rob J. Van der Geest, Andrew J. Swift, Jonathan C.L. Rodrigues, Pankaj Garg, Nikhil V. Joshi, Amardeep Dastidar

Research output: Contribution to journalReview articlepeer-review

1 Citation (SciVal)


Coronary artery disease (CAD) remains a leading cause of mortality and morbidity worldwide, and it is associated with considerable economic burden. In an ageing, multimorbid population, it has become increasingly important to develop reliable, consistent, low-risk, non-invasive means of diagnosing CAD. The evolution of multiple cardiac modalities in this field has addressed this dilemma to a large extent, not only in providing information regarding anatomical disease, as is the case with coronary computed tomography angiography (CCTA), but also in contributing critical details about functional assessment, for instance, using stress cardiac magnetic resonance (S-CMR). The field of artificial intelligence (AI) is developing at an astounding pace, especially in healthcare. In healthcare, key milestones have been achieved using AI and machine learning (ML) in various clinical settings, from smartwatches detecting arrhythmias to retinal image analysis and skin cancer prediction. In recent times, we have seen an emerging interest in developing AI-based technology in the field of cardiovascular imaging, as it is felt that ML methods have potential to overcome some limitations of current risk models by applying computer algorithms to large databases with multidimensional variables, thus enabling the inclusion of complex relationships to predict outcomes. In this paper, we review the current literature on the various applications of AI in the assessment of CAD, with a focus on multimodality imaging, followed by a discussion on future perspectives and critical challenges that this field is likely to encounter as it continues to evolve in cardiology.

Original languageEnglish
JournalMedical sciences (Basel, Switzerland)
Issue number1
Early online date24 Feb 2023
Publication statusPublished - 31 Mar 2023
Externally publishedYes

Bibliographical note

Funding: This study is partly funded by the Wellcome Trust Award to PG (220703/Z/20/Z). For the purpose of Open Access, this author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. Nikhil V. Joshi is supported by the Medical Research Council through MRC Clinical Academic Research Partnership grant (MR/T005459/1).

Data Availability Statement: Not applicable.


  • artificial intelligence
  • cardiac imaging
  • coronary artery disease

ASJC Scopus subject areas

  • Medicine(all)


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