Are there age and racial differences to methyl nicotinate—induced vasodilatation in human skin?

Richard H. Guy, Ethel Tur, Scott Bjerke, Howard I. Maibach

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Preliminary experiments have been performed to determine whether there are age and racial differences in the response of human skin to the topically applied vasodilator methyl nicotinate. With the use of a constant stimulus (a 15-second exposure to a 100 mM aqueous solution of drug), the subsequent time-course of the vasodilatation response was followed noninvasively and objectively with the optical technics of laser Doppler velocimetry (LDV) and photoplethysmography (PPG). Three groups of subjects were considered: young white subjects (20 to 30 years of age), elderly white subjects (63 to 80 years old), and young black subjects (20 to 30 years old). Analysis of the results shows that the time to peak response, the area under the response-time curve, and the time for the response to decay to 75% of its maximum value are statistically indistinguishable for all three groups at the p = 0.05 level of significance. Only the magnitude of the peak response revealed some significant differences between the cohorts (young>black, determined by PPG; young>old, determined by LDV). The data suggest, therefore, a remarkable similarity in response across a wide range of skin types. The origin of this consistency may, however, be complex and is not revealed by these experiments.

Original languageEnglish
Pages (from-to)1001-1006
Number of pages6
JournalJournal of the American Academy of Dermatology
Issue number6
Publication statusPublished - 30 Jun 1985

Bibliographical note

Funding Information:
From the Departments Of Pharmacy and Pharmaceutical Chemistry, School of Pharmacy (Dr. Guy), and the Department of Dermatol-ogy, Scho61 of Medicine (Drs, Tur, Bjerke, and Maibach), Uni-versity of California, San Francisco. Supported by National Institutes of Health Grant No. AG-04851 from the National Institutes on Aging (Dr. Guy) and by Ciba-Geigy. Accepted for publication Dec. 20, 1984. Re.print requests to: Dr. Richard l-I. Guy, School of Pharmacy, De-partrnent, of Pharmaceutical Chemistry, University of California, .Sala Franeiseo, CA 94143/415-666-4830, *A preliminary report of this work appears in Clinical Research, vol, 32, pp. 138A, 587A, 1984. **Permanent address: Ichilov Medical Center, Dermatology Depart-ment, Tel Aviv, Israel.

ASJC Scopus subject areas

  • Dermatology


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