TY - JOUR
T1 - Are environmentally coupled enzymatic hydrogen tunneling reactions influenced by changes in solution viscosity?
AU - Hay, Sam
AU - Pudney, Christopher
AU - Sutcliffe, Michael J
AU - Scrutton, Nigel S
PY - 2008/1/4
Y1 - 2008/1/4
N2 - Light at the end of the tunnel? The rate and kinetic isotope effect of an enzymatic H-tunneling reaction are not dependent on solution viscosity (see picture), despite clear evidence that this reaction is coupled to promoting motions within the protein. This finding is in contrast to the viscosity dependence of conformationally gated electron-transfer reactions and suggests that the mechanisms of environmental gating of these reactions are different.
AB - Light at the end of the tunnel? The rate and kinetic isotope effect of an enzymatic H-tunneling reaction are not dependent on solution viscosity (see picture), despite clear evidence that this reaction is coupled to promoting motions within the protein. This finding is in contrast to the viscosity dependence of conformationally gated electron-transfer reactions and suggests that the mechanisms of environmental gating of these reactions are different.
UR - http://www.scopus.com/inward/record.url?scp=38949173267&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1002/anie.200704484
U2 - 10.1002/anie.200704484
DO - 10.1002/anie.200704484
M3 - Article
SN - 1433-7851
VL - 47
SP - 537
EP - 540
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
IS - 3
ER -