Approximation of definable sets by compact families, and upper bounds on homotopy and homology

We prove new upper bounds on homotopy and homology groups of o-minimal sets in terms of their approximations by compact o-minimal sets. In particular, we improve the known upper bounds on Betti numbers of semialgebraic sets defined by quantifier-free formulae and obtain, for the first time, a singly exponential bound on Betti numbers of sub-Pfaffian sets.