Approaches and methods to study wildlife cancer

Mathieu Giraudeau; Orsolya Vincze; Sophie M. Dupont; Tuul Sepp; Ciara Baines; Jean Francois Lemaitre; Karin Lemberger; Sophie Gentès; Amy Boddy; Antoine M. Dujon; Georgina Bramwell; Valerie Harris; Beata Ujvari; Catherine Alix-Panabières; Stephane Lair; David Sayag; Dalia A. Conde; Fernando Colchero; Tara M. Harrison; Samuel Pavard; Benjamin Padilla-Morales; Damien Chevallier; Rodrigo Hamede; Benjamin Roche; Tamas Malkocs; Athena C. Aktipis; Carlo Maley; James DeGregori; Guillaume Le Loc’h; Frédéric Thomas

doi:10.1111/1365-2656.14144

Approaches and methods to study wildlife cancer

Mathieu Giraudeau
, Orsolya Vincze
, Sophie M. Dupont
, Tuul Sepp
, Ciara Baines
, Jean Francois Lemaitre
, Karin Lemberger
, Sophie Gentès
, Amy Boddy
, Antoine M. Dujon
, Georgina Bramwell
, Valerie Harris
, Beata Ujvari
, Catherine Alix-Panabières
, Stephane Lair
, David Sayag
, Dalia A. Conde
, Fernando Colchero
, Tara M. Harrison
, Samuel Pavard

Benjamin Padilla-Morales, Damien Chevallier, Rodrigo Hamede, Benjamin Roche, Tamas Malkocs, Athena C. Aktipis, Carlo Maley, James DeGregori, Guillaume Le Loc’h, Frédéric Thomas

Department of Life Sciences

Littoral Environnement et Sociétés (LIENSs)
University of Bordeaux
Babeş-Bolyai University
HUN-REN–UD Conservation Biology Research Group
Institut d'Astrophysique de Paris
University of Tartu
Leeds Metropolitan University
Université Claude Bernard Lyon 1
Vet Diagnostics
University of California Santa Barbara
Deakin University
IRD 224–CNRS5290–Université de Montpellier
Arizona State University
Centre de Recherches Ecologiques et Evolutives sur le Cancer
University Medical Centre of Montpellier
Université de Montréal
ONCOnseil—Unité d'expertise en oncologie vétérinaire
University of Southern Denmark
Max Planck Institute for Evolutionary Anthropology
North Carolina State University
Université Paris Cité
Centre for Therapeutic Innovation University of Bath
University of Tasmania
Centre de Recherche en Écologie et Évolution de la Santé (CREES)
Universidad Nacional Autónoma de México
IUEM
University of Colorado School of Medicine
École Nationale Vétérinaire de Toulouse

Research output: Contribution to journal › Article › peer-review

2 Citations (SciVal)

Abstract

The last few years have seen a surge of interest from field ecologists and evolutionary biologists to study neoplasia and cancer in wildlife. This contributes to the One Health Approach, which investigates health issues at the intersection of people, wild and domestic animals, together with their changing environments. Nonetheless, the emerging field of wildlife cancer is currently constrained by methodological limitations in detecting cancer using non-invasive sampling. In addition, the suspected differential susceptibility and resistance of species to cancer often make the choice of a unique model species difficult for field biologists. Here, we provide an overview of the importance of pursuing the study of cancer in non-model organisms and we review the currently available methods to detect, measure and quantify cancer in the wild, as well as the methodological limitations to be overcome to develop novel approaches inspired by diagnostic techniques used in human medicine. The methodology we propose here will help understand and hopefully fight this major disease by generating general knowledge about cancer, variation in its rates, tumour-suppressor mechanisms across species as well as its link to life history and physiological characters. Moreover, this is expected to provide key information about cancer in wildlife, which is a top priority due to the accelerated anthropogenic change in the past decades that might favour cancer progression in wild populations.

Original language	English
Pages (from-to)	1410-1428
Number of pages	19
Journal	Journal of Animal Ecology
Volume	93
Issue number	10
Early online date	27 Aug 2024
DOIs	https://doi.org/10.1111/1365-2656.14144
Publication status	Published - 31 Oct 2024

Funding

We express our gratitude to the two anonymous reviewers and the Associate Editor for their meticulous reviews and valuable contributions that greatly enhanced the quality of this work. MG was supported by the ANR COVER (ANR-23-CE02-0019) and the Chaire d'excellence \u2018Cancer et Biodiversit\u00E9\u2019. OV was supported by the National Scientific Research Fund (OTKA K143421). SMD was supported by the Fonds Europ\u00E9en de D\u00E9veloppement R\u00E9gional PO/FEDER/FSE 2014-2020 - Collectivit\u00E9 Territoriale de Martinique (Convention N\u00B0 MQ0017449). CCM was supported in part by NIH grants U54 CA217376, U2C CA233254, P01 CA91955 and R01 CA140657 as well as CDMRP Breast Cancer Research Program Award BC132057 and the Arizona Biomedical Research Commission grant ADHS18-198847. FT is supported by the CNRS, the Hoffmann Family and by the following grant: EVOSEXCAN project (ANR-23-CE13-0007). TS was supported by the Estonian Research Council grant PSG653, RH by Australian Research Council (DE170101116 and LP170101105), AOU by a PAPPIT-DGAPA-UNAM grant (IN200920), a Natural Environment Research Council grant (NE/P004121/1), and Royal Society Funding (DH071902, RG0870644 and RG080272), CAP by the ELBA project that has received funding from the European Union Horizon 2020 Research and Innovation Program under the Marie Sk\u0142odowska-Curie grant agreement no.: 765492. CAP is also supported by the National Institute of Cancer (INCa, http://www.e-cancer.fr), SIRIC Montpellier Cancer Grant INCa_Inserm_DGOS_12553 and the ERA-NET TRANSCAN 2 JTC 2016 PROLIPSY. We thank Vivian Klimushev for authoring Figure\u00A01. We express our gratitude to the two anonymous reviewers and the Associate Editor for their meticulous reviews and valuable contributions that greatly enhanced the quality of this work. MG was supported by the ANR COVER (ANR\u201023\u2010CE02\u20100019) and the Chaire d'excellence \u2018Cancer et Biodiversit\u00E9\u2019. OV was supported by the National Scientific Research Fund (OTKA K143421). SMD was supported by the Fonds Europ\u00E9en de D\u00E9veloppement R\u00E9gional PO/FEDER/FSE 2014\u20102020 \u2010 Collectivit\u00E9 Territoriale de Martinique (Convention N\u00B0 MQ0017449). CCM was supported in part by NIH grants U54 CA217376, U2C CA233254, P01 CA91955 and R01 CA140657 as well as CDMRP Breast Cancer Research Program Award BC132057 and the Arizona Biomedical Research Commission grant ADHS18\u2010198847. FT is supported by the CNRS, the Hoffmann Family and by the following grant: EVOSEXCAN project (ANR\u201023\u2010CE13\u20100007). TS was supported by the Estonian Research Council grant PSG653, RH by Australian Research Council (DE170101116 and LP170101105), AOU by a PAPPIT\u2010DGAPA\u2010UNAM grant (IN200920), a Natural Environment Research Council grant (NE/P004121/1), and Royal Society Funding (DH071902, RG0870644 and RG080272), CAP by the ELBA project that has received funding from the European Union Horizon 2020 Research and Innovation Program under the Marie Sk\u0142odowska\u2010Curie grant agreement no.: 765492. CAP is also supported by the National Institute of Cancer (INCa, http://www.e\u2010cancer.fr ), SIRIC Montpellier Cancer Grant INCa_Inserm_DGOS_12553 and the ERA\u2010NET TRANSCAN 2 JTC 2016 PROLIPSY. We thank Vivian Klimushev for authoring Figure 1 .

Funders	Funder number
H2020 Marie Skłodowska-Curie Actions
Centre national de la recherche scientifique
National Cancer Institute
ELBA
PAPPIT-DGAPA-UNAM
EU - Horizon 2020	765492
Arizona Biomedical Research Commission	ADHS18‐198847
Australian Research Council	DE170101116, LP170101105
Institut National Du Cancer	12553, DGOS_12553
Eesti Teadusagentuur	PSG653
Collectivité Territoriale de Martinique	MQ0017449
American Ornithologists' Union	IN200920
European Regional Development Fund	MQ0017449
French National Research Agency	ANR‐23‐CE02‐0019
National Institutes of Health	BC132057, U54 CA217376, P01 CA91955, U2C CA233254, R01 CA140657
Royal Society	DH071902, RG080272, RG0870644
Natural Environment Research Council	NE/P004121/1
National Scientific Research Fund	OTKA K143421
Hoffmann Family	ANR‐23‐CE13‐0007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer
cancer diagnostic
disease ecology
One Health
wildlife disease

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Animal Science and Zoology

Access to Document

10.1111/1365-2656.14144Licence: CC BY

Cite this

Giraudeau, M., Vincze, O., Dupont, S. M., Sepp, T., Baines, C., Lemaitre, J. F., Lemberger, K., Gentès, S., Boddy, A., Dujon, A. M., Bramwell, G., Harris, V., Ujvari, B., Alix-Panabières, C., Lair, S., Sayag, D., Conde, D. A., Colchero, F., Harrison, T. M., ... Thomas, F. (2024). Approaches and methods to study wildlife cancer. Journal of Animal Ecology, 93(10), 1410-1428. https://doi.org/10.1111/1365-2656.14144

Giraudeau, M, Vincze, O, Dupont, SM, Sepp, T, Baines, C, Lemaitre, JF, Lemberger, K, Gentès, S, Boddy, A, Dujon, AM, Bramwell, G, Harris, V, Ujvari, B, Alix-Panabières, C, Lair, S, Sayag, D, Conde, DA, Colchero, F, Harrison, TM, Pavard, S, Padilla-Morales, B, Chevallier, D, Hamede, R, Roche, B, Malkocs, T, Aktipis, AC, Maley, C, DeGregori, J, Le Loc’h, G & Thomas, F 2024, 'Approaches and methods to study wildlife cancer', Journal of Animal Ecology, vol. 93, no. 10, pp. 1410-1428. https://doi.org/10.1111/1365-2656.14144

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title = "Approaches and methods to study wildlife cancer",

abstract = "The last few years have seen a surge of interest from field ecologists and evolutionary biologists to study neoplasia and cancer in wildlife. This contributes to the One Health Approach, which investigates health issues at the intersection of people, wild and domestic animals, together with their changing environments. Nonetheless, the emerging field of wildlife cancer is currently constrained by methodological limitations in detecting cancer using non-invasive sampling. In addition, the suspected differential susceptibility and resistance of species to cancer often make the choice of a unique model species difficult for field biologists. Here, we provide an overview of the importance of pursuing the study of cancer in non-model organisms and we review the currently available methods to detect, measure and quantify cancer in the wild, as well as the methodological limitations to be overcome to develop novel approaches inspired by diagnostic techniques used in human medicine. The methodology we propose here will help understand and hopefully fight this major disease by generating general knowledge about cancer, variation in its rates, tumour-suppressor mechanisms across species as well as its link to life history and physiological characters. Moreover, this is expected to provide key information about cancer in wildlife, which is a top priority due to the accelerated anthropogenic change in the past decades that might favour cancer progression in wild populations.",

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AU - Lemaitre, Jean Francois

AU - Lemberger, Karin

AU - Gentès, Sophie

AU - Boddy, Amy

AU - Dujon, Antoine M.

AU - Bramwell, Georgina

AU - Harris, Valerie

AU - Ujvari, Beata

AU - Alix-Panabières, Catherine

AU - Lair, Stephane

AU - Sayag, David

AU - Conde, Dalia A.

AU - Colchero, Fernando

AU - Harrison, Tara M.

AU - Pavard, Samuel

AU - Padilla-Morales, Benjamin

AU - Chevallier, Damien

AU - Hamede, Rodrigo

AU - Roche, Benjamin

AU - Malkocs, Tamas

AU - Aktipis, Athena C.

AU - Maley, Carlo

AU - DeGregori, James

AU - Le Loc’h, Guillaume

AU - Thomas, Frédéric

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N2 - The last few years have seen a surge of interest from field ecologists and evolutionary biologists to study neoplasia and cancer in wildlife. This contributes to the One Health Approach, which investigates health issues at the intersection of people, wild and domestic animals, together with their changing environments. Nonetheless, the emerging field of wildlife cancer is currently constrained by methodological limitations in detecting cancer using non-invasive sampling. In addition, the suspected differential susceptibility and resistance of species to cancer often make the choice of a unique model species difficult for field biologists. Here, we provide an overview of the importance of pursuing the study of cancer in non-model organisms and we review the currently available methods to detect, measure and quantify cancer in the wild, as well as the methodological limitations to be overcome to develop novel approaches inspired by diagnostic techniques used in human medicine. The methodology we propose here will help understand and hopefully fight this major disease by generating general knowledge about cancer, variation in its rates, tumour-suppressor mechanisms across species as well as its link to life history and physiological characters. Moreover, this is expected to provide key information about cancer in wildlife, which is a top priority due to the accelerated anthropogenic change in the past decades that might favour cancer progression in wild populations.

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KW - disease ecology

KW - One Health

KW - wildlife disease

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JO - Journal of Animal Ecology

JF - Journal of Animal Ecology

IS - 10

ER -

Approaches and methods to study wildlife cancer

Abstract

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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