Abstract
The dearomatising dihydroxylation of aromatic molecules mediated by arene dioxygenase enzymes can provide cyclohexadiene-diols that are versatile starting materials for organic synthesis. Whereas oxidation of a substituted arene to give its ortho,meta-dihydrodiol has been demonstrated for numerous substrates and dioxygenases, formation of ipso,ortho-dihydrodiols has historically been underutilised in comparison. This feature article presents a chronological account of reported uses of such diols.
| Original language | English |
|---|---|
| Pages (from-to) | 2821-2830 |
| Number of pages | 10 |
| Journal | Chemical Communications |
| Volume | 50 |
| Issue number | 22 |
| Early online date | 11 Feb 2014 |
| DOIs | |
| Publication status | Published - 11 Feb 2014 |