Application of a novel oscillatory flow micro-bioreactor to the production of γ-decalactone in a two immiscible liquid phase medium

N. Reis, C. N. Gonçalves, M. Aguedo, N. Gomes, J. A. Teixeira, A. A. Vicente

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A novel micro-bioreactor based on the oscillatory flow technology was applied to the scale-down of the biotechnological production of γ-decalactone. A decrease up to 50% of the time required to obtain the maximum concentration of the compound was observed, when compared with other scaled-down platforms (stirred tank bioreactor or shake flask). A three-fold increase in γ-decalactone productivity was obtained by increasing oscillatory mixing intensity from Re o ∼482 to Re o ∼1447. This was presumably related to the effective contribution of the reactor geometry to enhanced mass transfer rates between the two immiscible liquid phases involved in the process by increasing the interfacial area.

Original languageEnglish
Pages (from-to)485-490
Number of pages6
JournalBiotechnology Letters
Volume28
Issue number7
DOIs
Publication statusPublished - 1 Apr 2006

Fingerprint

Bioreactors
Liquids
Mass transfer
Productivity
Technology
Geometry
decan-4-olide

Keywords

  • γ-decalactone
  • Micro-bioreactor
  • Mixing
  • Oscillatory flow
  • Screening
  • Two immiscible liquid phases
  • Yarrowia lipolytica

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Bioengineering

Cite this

Application of a novel oscillatory flow micro-bioreactor to the production of γ-decalactone in a two immiscible liquid phase medium. / Reis, N.; Gonçalves, C. N.; Aguedo, M.; Gomes, N.; Teixeira, J. A.; Vicente, A. A.

In: Biotechnology Letters, Vol. 28, No. 7, 01.04.2006, p. 485-490.

Research output: Contribution to journalArticle

Reis, N. ; Gonçalves, C. N. ; Aguedo, M. ; Gomes, N. ; Teixeira, J. A. ; Vicente, A. A. / Application of a novel oscillatory flow micro-bioreactor to the production of γ-decalactone in a two immiscible liquid phase medium. In: Biotechnology Letters. 2006 ; Vol. 28, No. 7. pp. 485-490.
@article{7ea3bf15d7aa4c29ac442127e22a135b,
title = "Application of a novel oscillatory flow micro-bioreactor to the production of γ-decalactone in a two immiscible liquid phase medium",
abstract = "A novel micro-bioreactor based on the oscillatory flow technology was applied to the scale-down of the biotechnological production of γ-decalactone. A decrease up to 50{\%} of the time required to obtain the maximum concentration of the compound was observed, when compared with other scaled-down platforms (stirred tank bioreactor or shake flask). A three-fold increase in γ-decalactone productivity was obtained by increasing oscillatory mixing intensity from Re o ∼482 to Re o ∼1447. This was presumably related to the effective contribution of the reactor geometry to enhanced mass transfer rates between the two immiscible liquid phases involved in the process by increasing the interfacial area.",
keywords = "γ-decalactone, Micro-bioreactor, Mixing, Oscillatory flow, Screening, Two immiscible liquid phases, Yarrowia lipolytica",
author = "N. Reis and Gon{\cc}alves, {C. N.} and M. Aguedo and N. Gomes and Teixeira, {J. A.} and Vicente, {A. A.}",
year = "2006",
month = "4",
day = "1",
doi = "10.1007/s10529-006-0003-x",
language = "English",
volume = "28",
pages = "485--490",
journal = "Biotechnology Letters",
issn = "0141-5492",
publisher = "Springer Netherlands",
number = "7",

}

TY - JOUR

T1 - Application of a novel oscillatory flow micro-bioreactor to the production of γ-decalactone in a two immiscible liquid phase medium

AU - Reis, N.

AU - Gonçalves, C. N.

AU - Aguedo, M.

AU - Gomes, N.

AU - Teixeira, J. A.

AU - Vicente, A. A.

PY - 2006/4/1

Y1 - 2006/4/1

N2 - A novel micro-bioreactor based on the oscillatory flow technology was applied to the scale-down of the biotechnological production of γ-decalactone. A decrease up to 50% of the time required to obtain the maximum concentration of the compound was observed, when compared with other scaled-down platforms (stirred tank bioreactor or shake flask). A three-fold increase in γ-decalactone productivity was obtained by increasing oscillatory mixing intensity from Re o ∼482 to Re o ∼1447. This was presumably related to the effective contribution of the reactor geometry to enhanced mass transfer rates between the two immiscible liquid phases involved in the process by increasing the interfacial area.

AB - A novel micro-bioreactor based on the oscillatory flow technology was applied to the scale-down of the biotechnological production of γ-decalactone. A decrease up to 50% of the time required to obtain the maximum concentration of the compound was observed, when compared with other scaled-down platforms (stirred tank bioreactor or shake flask). A three-fold increase in γ-decalactone productivity was obtained by increasing oscillatory mixing intensity from Re o ∼482 to Re o ∼1447. This was presumably related to the effective contribution of the reactor geometry to enhanced mass transfer rates between the two immiscible liquid phases involved in the process by increasing the interfacial area.

KW - γ-decalactone

KW - Micro-bioreactor

KW - Mixing

KW - Oscillatory flow

KW - Screening

KW - Two immiscible liquid phases

KW - Yarrowia lipolytica

UR - http://www.scopus.com/inward/record.url?scp=33645859582&partnerID=8YFLogxK

U2 - 10.1007/s10529-006-0003-x

DO - 10.1007/s10529-006-0003-x

M3 - Article

VL - 28

SP - 485

EP - 490

JO - Biotechnology Letters

JF - Biotechnology Letters

SN - 0141-5492

IS - 7

ER -