Application of a novel oscillatory flow micro-bioreactor to the production of γ-decalactone in a two immiscible liquid phase medium

N. Reis, C. N. Gonçalves, M. Aguedo, N. Gomes, J. A. Teixeira, A. A. Vicente

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A novel micro-bioreactor based on the oscillatory flow technology was applied to the scale-down of the biotechnological production of γ-decalactone. A decrease up to 50% of the time required to obtain the maximum concentration of the compound was observed, when compared with other scaled-down platforms (stirred tank bioreactor or shake flask). A three-fold increase in γ-decalactone productivity was obtained by increasing oscillatory mixing intensity from Re o ∼482 to Re o ∼1447. This was presumably related to the effective contribution of the reactor geometry to enhanced mass transfer rates between the two immiscible liquid phases involved in the process by increasing the interfacial area.

Original languageEnglish
Pages (from-to)485-490
Number of pages6
JournalBiotechnology Letters
Volume28
Issue number7
DOIs
Publication statusPublished - 1 Apr 2006

Keywords

  • γ-decalactone
  • Micro-bioreactor
  • Mixing
  • Oscillatory flow
  • Screening
  • Two immiscible liquid phases
  • Yarrowia lipolytica

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Bioengineering

Fingerprint Dive into the research topics of 'Application of a novel oscillatory flow micro-bioreactor to the production of γ-decalactone in a two immiscible liquid phase medium'. Together they form a unique fingerprint.

  • Cite this