Application of a multiplex microfluidic platform to fast polymorph screening of pharmaceutical compounds

E. Simone, J. McVeigh, Z. K. Nagy, N. M. Reis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Polymorphism is known as the ability of a compound to exist in more than one crystalline structure, and is very common in the crystallization of active pharmaceutical ingredients (APIs). Polymorph screening is fundamental during the development of new drugs since the formation of the wrong polymorph can affect solubility, rate of dissolution and toxicity of the API, therefore, seriously threatening the life of patients [1]. This work reports a novel microfluidic method for studying polymorphism based on multiplex fluoropolymer microfluidic devices.

Original languageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages910-911
Number of pages2
ISBN (Electronic)9780979806490
Publication statusPublished - 1 Jan 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: 9 Oct 201613 Oct 2016

Conference

Conference20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period9/10/1613/10/16

Fingerprint

Polymorphism
Microfluidics
Drug products
Screening
Fluorine containing polymers
Toxicity
Dissolution
Solubility
Crystallization
Crystalline materials

Keywords

  • Crystallization
  • Micro capillary film
  • Polymorph screening

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Simone, E., McVeigh, J., Nagy, Z. K., & Reis, N. M. (2016). Application of a multiplex microfluidic platform to fast polymorph screening of pharmaceutical compounds. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (pp. 910-911). Chemical and Biological Microsystems Society.

Application of a multiplex microfluidic platform to fast polymorph screening of pharmaceutical compounds. / Simone, E.; McVeigh, J.; Nagy, Z. K.; Reis, N. M.

20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. p. 910-911.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Simone, E, McVeigh, J, Nagy, ZK & Reis, NM 2016, Application of a multiplex microfluidic platform to fast polymorph screening of pharmaceutical compounds. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, pp. 910-911, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Dublin, Ireland, 9/10/16.
Simone E, McVeigh J, Nagy ZK, Reis NM. Application of a multiplex microfluidic platform to fast polymorph screening of pharmaceutical compounds. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society. 2016. p. 910-911
Simone, E. ; McVeigh, J. ; Nagy, Z. K. ; Reis, N. M. / Application of a multiplex microfluidic platform to fast polymorph screening of pharmaceutical compounds. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. pp. 910-911
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