Apoptosis as a therapeutic target for the treatment of lung disease

Patricia M. de Souza, Mark A. Lindsay

Research output: Contribution to journalReview articlepeer-review

Abstract

It has been speculated that the destruction of lung tissue, associated with several acute and chronic diseases, is in part mediated through apoptosis or programmed cell death. Thus, it has been shown that both increased endothelial/epithelial cell apoptosis and decreased cell death of inflammatory cells are associated with acute lung injury/acute respiratory distress syndrome, chronic obstructive pulmonary disease, asthma and pulmonary fibrosis. In the light of these observations, it might be possible to use apoptosis modulation as a novel therapeutic approach to the treatment of lung disease.

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume5
Issue number3 SPEC. ISS.
DOIs
Publication statusPublished - 30 Jun 2005

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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