Abstract

Hydrogel-forming microneedle arrays as a technique for transdermal drug delivery show promise as an alternative to traditional drug delivery methods. In this work, hydrogel-forming microneedles have been created with effective, controlled delivery of amoxicillin and vancomycin within comparable therapeutic ranges to that of oral delivered antibiotics. Fabrication using reusable 3D printed master templates enabled quick and low-cost hydrogel microneedle manufacturing through micro-molding. By 3D printing at a tilt angle of 45° the resolution of the microneedle tip was improved by double (from ca. 64 μm down to 23 μm). Amoxicillin and vancomycin were encapsulated within the hydrogel's polymeric network through a unique room temperature swell/deswell drug loading method within minutes, eliminating the need for an external drug reservoir. The hydrogel-forming microneedle mechanical strength was maintained, and successful penetration of porcine skin grafts observed with negligible damage to the needles or surrounding skin morphology. Hydrogel swell rate was tailored by altering the crosslinking density, resulting in controlled antimicrobial release for an applicable delivered dosage. The potent antimicrobial properties of the antibiotic-loaded hydrogel-forming microneedles against both Escherichia coli and Staphylococcus aureus, highlights the beneficial use of hydrogel-forming microneedles towards the minimally invasive transdermal drug delivery of antibiotics.
Original languageEnglish
Article number213467
Number of pages11
JournalBiomaterials Advances
Volume151
Early online date23 May 2023
DOIs
Publication statusPublished - 31 Aug 2023

Bibliographical note

JGT and HSL thank Abbott Diabetes Care Ltd. and EPSRC EP/R513155/1 for their funding support. H.S.L. acknowledges the EPSRC EP/V010859/1, and the Royal Society Research Grant RSG\R1\201185 for their support.

Data availability
The data that support the findings of this study are openly available in Dataset for “Antimicrobial Releasing Hydrogel-forming microneedles” at https://doi.org/10.15125/BATH-01176.

Funding Information:
JGT and HSL thank Abbott Diabetes Care Ltd. and EPSRC EP/R513155/1 for their funding support. H.S.L. acknowledges the EPSRC EP/V010859/1 , and the Royal Society Research Grant RSG\R1\201185 for their support. The authors would like to thank Professor Richard Guy for his expertise and donation of porcine skin during experimentation. Additionally, the authors would like to thank the reviewers for their constructive feedback.

Keywords

  • 3D-printing
  • Antimicrobial properties
  • Hydrogel-forming microneedles
  • Skin penetration
  • Transdermal drug delivery

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Biomaterials

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