Multidrug resistance of bacterial pathogens is a major problem and there is a clear need for the development of new types of antibiotics. Here we investigated the antimicrobial activity of ruthenium(II) based DNA-intercalating complexes. These complexes were found to have no activity in vitro against the Gram-negative bacterium Escherichia coil, but the complexes were clearly active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. In vivo activity has also been demonstrated for one of the compounds using a simple infection model, the nematode Caenorhabditis elegans. Importantly, this also showed that the compound tested was not toxic to the nematodes.
- methicillin-resistant staphylococcus aureus
- DNA intercalator
- caenorhabditis elegans
- ruthenium complexes
- antimicrobial agents
Bolhuis, A., Hand, L., Marshall, J. E., Richards, A. D., Rodger, A., & Aldrich-Wright, J. (2011). Antimicrobial activity of ruthenium-based intercalators. European Journal of Pharmaceutical Sciences, 42(4), 313-317. https://doi.org/10.1016/j.ejps.2010.12.004