Antimicrobial activity of ruthenium-based intercalators

Albert Bolhuis, L Hand, J E Marshall, A D Richards, A Rodger, J Aldrich-Wright

Research output: Contribution to journalArticle

88 Citations (Scopus)
154 Downloads (Pure)

Abstract

Multidrug resistance of bacterial pathogens is a major problem and there is a clear need for the development of new types of antibiotics. Here we investigated the antimicrobial activity of ruthenium(II) based DNA-intercalating complexes. These complexes were found to have no activity in vitro against the Gram-negative bacterium Escherichia coil, but the complexes were clearly active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. In vivo activity has also been demonstrated for one of the compounds using a simple infection model, the nematode Caenorhabditis elegans. Importantly, this also showed that the compound tested was not toxic to the nematodes.
Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalEuropean Journal of Pharmaceutical Sciences
Volume42
Issue number4
DOIs
Publication statusPublished - 18 Mar 2011

Keywords

  • methicillin-resistant staphylococcus aureus
  • DNA intercalator
  • caenorhabditis elegans
  • ruthenium complexes
  • antimicrobial agents

Fingerprint Dive into the research topics of 'Antimicrobial activity of ruthenium-based intercalators'. Together they form a unique fingerprint.

  • Cite this

    Bolhuis, A., Hand, L., Marshall, J. E., Richards, A. D., Rodger, A., & Aldrich-Wright, J. (2011). Antimicrobial activity of ruthenium-based intercalators. European Journal of Pharmaceutical Sciences, 42(4), 313-317. https://doi.org/10.1016/j.ejps.2010.12.004